Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray.
Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray.
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DOI：
10.1039/c5lc01010a
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发表时间：
2015-11
期刊：
影响因子：
6.1
通讯作者：
Zihua Wang;Weizhi Wang;Lingling Geng;Zhiyuan Hu
中科院分区：
文献类型：
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作者：
Zihua Wang;Weizhi Wang;Lingling Geng;Zhiyuan Hu
构建了一个硅基微阵列系统，以发现亲和肽，并从高通量文库中区分特异性肽。使用颜色编码策略，实现了HER1配体和HER2配体之间的原位肽区分。以nmol亲和力测定新的亲和肽序列H1P（HER1配体）和H2P（HER2配体）。
A silicon-based microarray system was constructed to discover the affinity peptides and to distinguish the specific peptides from a high throughput library. Using a color-encoding strategy, in situ peptide distinguishing between HER1 ligands and HER2 ligands was achieved. Novel affinity peptide sequences H1P (HER1 ligand) and H2P (HER2 ligand) were determined with nmol affinity.