The switching dynamics of the bacterial flagellar motor.
The switching dynamics of the bacterial flagellar motor.
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DOI：
10.1038/msb.2009.74
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发表时间：
2009
影响因子：
9.9
通讯作者：
中科院分区：
文献类型：
--
作者：
许多细菌是由鞭毛马达推动的，它在顺时针和逆时针的旋转方向之间随机切换。虽然开关动力学是它们最重要的特征之一，但控制它的机制却知之甚少。我们提出了细菌鞭毛运动的统计力学模型。其核心假设是，与鞭毛相连的转子蛋白复合物可以存在于两种构象状态，而这些状态之间的切换取决于与驱动转子的定子蛋白的相互作用。这对切换到旋转，使开关对扭矩和速度敏感。另一个关键因素是，在转换之后，由于鞭毛的构象转变，负载需要时间来积累。正如最近观察到的那样，灯丝的这种缓慢弛豫动力学，结合开关频率的负载依赖性，导致了一个特征开关时间。因此，我们的模型预测，开关动力学不仅由趋化信号网络控制，而且由鞭毛的机械反馈控制。
Many bacteria are propelled by flagellar motors that stochastically switch between the clockwise and counterclockwise rotation direction. Although the switching dynamics is one of their most important characteristics, the mechanisms that control it are poorly understood. We present a statistical–mechanical model of the bacterial flagellar motor. At its heart is the assumption that the rotor protein complex, which is connected to the flagellum, can exist in two conformational states and that switching between these states depends on the interactions with the stator proteins, which drive the rotor. This couples switching to rotation, making the switch sensitive to torque and speed. Another key element is that after a switch, it takes time for the load to build up, due to conformational transitions of the flagellum. This slow relaxation dynamics of the filament leads, in combination with the load dependence of the switching frequency, to a characteristic switching time, as recently observed. Hence, our model predicts that the switching dynamics is not only controlled by the chemotaxis-signaling network, but also by mechanical feedback of the flagellum.
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影响因子：
3.2
作者：
Thomas, Dennis R.;Francis, Noreen R.;DeRosier, David J.
通讯作者：
DeRosier, David J.
影响因子：
3.2
作者：
Darnton, Nicholas C.;Turner, Linda;Berg, Howard C.
通讯作者：
Berg, Howard C.
影响因子：
5.6
作者：
Duke, TAJ;Le Novère, N;Bray, D
通讯作者：
Bray, D
DOI：
10.1073/pnas.0507959103
发表时间：
2006-01-31
影响因子：
11.1
作者：
Xing, JH;Bai, F;Oster, G
通讯作者：
Oster, G
影响因子：
64.8
作者：
CALLADINE, CR
通讯作者：
CALLADINE, CR