Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes
Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes
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DOI：
10.1136/bjophthalmol-2018-312401
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发表时间：
2019-07-01
影响因子：
4.1
通讯作者：
Webers, Carroll A. B.
中科院分区：
文献类型：
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作者：
Venugopal, Jayasree P.;Rao, Harsha Laxmana;Webers, Carroll A. B.
目的比较正常眼和青光眼高密度(HD)和非HD光学相干断层血管成像(OCTA)扫描的乳头周围血管密度(VD)测量结果，评价HD扫描测量VD的可重复性。方法在横断面研究中，46例正常人(33例)和89例青光眼患者(患者)在同一时段进行了3次HD和1次非HD视神经头OCTA扫描。使用Bland和Altman分析评估HD和非HD扫描测量VD的一致性。使用受试者内重复性系数(CRW)和变异系数(CVW)评估HD扫描的Vd测量的重复性。结果VDS的平均差值介于0.7%(颞区VD)和2.0%(鼻下区VD)之间，HD扫描显示的VD值明显大于非HD扫描。青光眼的95%一致性限(LOA)在全面性VD的-2.0%-5.0%和颞叶上VD的-4.8%-9.6%之间。正常眼HD扫描VD值的CRW(%)和CVW(%)范围分别为3.0~4.9和2.0~3.1。青光眼分别为3.2~6.7和2.6~4.8。结论HD扫描的Vd高于非HD扫描的Vd。宽95%的LOA表明HD和非HD扫描的Vd测量不能互换使用。VDS在HD扫描上的重测重复性高达6%。在使用OCTA对青光眼进行纵向评估时，应考虑这些结果。
Aims To compare the peripapillary vessel density (VD) measurements of high-density (HD) and non-HD optical coherence tomography angiography (OCTA) scans in normal and glaucoma eyes, and to evaluate the intrasession repeatability of VD measurements of HD scans. Methods In a cross-sectional study, 46 normal (33 subjects) and 89 glaucoma (64 patients) eyes underwent 3 HD and 1 non-HD optic nerve head OCTA scans in the same session. Agreement in VD measurements between HD and non-HD scans was assessed using Bland and Altman analysis. Repeatability of the VD measurements of HD scans was assessed using within-subject coefficient of repeatability (CRw) and variation (CVw). Results The mean difference in the VDs ranged between 0.7% (temporal sector VD) and 2.0% (inferonasal sector VD), with HD scans showing significantly greater VD values than non-HD scans. The 95% limits of agreement (LoA) in glaucoma eyes ranged between -2.0% and 5.0% for whole enface VD and between -4.8% and 9.6% for superotemporal VD. CRw (%) and CVw (%) of VD measurements of HD scans ranged from 3.0 to 4.9 and from 2.0 to 3.1 in normal eyes. The same ranged from 3.2 to 6.7 and from 2.6 to 4.8, respectively, in glaucoma eyes. Conclusions VD of HD scans was higher than that of non-HD scans. The wide 95% LoA indicates that the VD measurements of HD and non-HD scans cannot be used interchangeably. Test-retest repeatability of VDs on HD scans was as high as 6%. These results should be considered while using OCTA for longitudinal evaluation of glaucoma.