Slowing of intestinal transit by fat depends on an ondansetron - sensitive, efferent serotonergic pathway.
Slowing of intestinal transit by fat depends on an ondansetron - sensitive, efferent serotonergic pathway.
复制标题
脂肪对肠道转运的减慢取决于昂丹司琼 - 敏感的传出血清素通路。
DOI：
10.1046/j.1365-2982.2003.00404.x
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Chen,JH
中科院分区：
文献类型：
--
作者：
Lin,HC;Chen,JH
回肠制动是一种神经反射，当脂肪进入远端小肠时，可减缓近端小肠运输。在大鼠中，5 -羟色胺- 3 （5 - HT3）受体拮抗剂昂丹司琼可消除回肠制动。然而，这种血清素能通路的位置尚不清楚。在已知的对5 -羟色胺（5 - HT）有反应的肠道部位中，只有肌内神经元具有5 - ht3受体，并且位于反射反应的传出肢体上。本研究的目的是验证一种假设，即脂肪减缓肠道运输可能取决于位于该反射反应的传出肢体上的昂丹西酮敏感的血清素能途径。在一个将回肠制动反应的传入和传出肢体分开的瘘管狗模型中，昂丹西酮被光输送到小肠的远端（传入）或近端（传出），以定位血清素能通路。结果发现，激活回肠制动使近端肠运输速度降低到控制值的30%。当昂丹司琼进入近端小肠而非远端小肠时，回肠制动消失。我们的数据支持这样的假设，即参与回肠制动的5‐HT受体位于这种神经反射的传出肢上，可能位于肌肠神经元上。
The ileal brake is a neural reflex that slows proximal small bowel transit when fat enters the distal small bowel. In rats, ondansetron, a 5‐hydroxytryptamine‐3 (5‐HT3)‐receptor antagonist, abolishes the ileal brake. However, the location of this serotonergic pathway is unknown. Of the known enteric sites responsive to 5‐hydroxytryptamine (5‐HT), only the myenteric neurone is equipped with 5‐HT3receptors and is located on the efferent limb of reflex response. The aim of this study was to test the hypothesis that slowing of intestinal transit by fat may depend on an ondansetron‐sensitive serotonergic pathway located on the efferent limb of this reflex response. In a fistulated dog model that compartmentalized the afferent from the efferent limb of the ileal brake response, ondansetron was delivered luminally into the distal (afferent) or proximal (efferent) half of the small bowel to localize the serotonergic pathway. It was found that activating the ileal brake slowed down the proximal intestinal transit to 30% of control values. The ileal brake was abolished when ondansetron was delivered into the proximal but not the distal small bowel. Our data supports the hypothesis that the 5‐HT receptors participating in the ileal brake are on the efferent limb of this neural reflex, possibly on myenteric neurones.