IDENTIFICATION OF AN INTERLEUKIN 2-LIKE SUBSTANCE AS A FACTOR CYTOTOXIC TO OLIGODENDROCYTES AND ASSOCIATED WITH CENTRAL-NERVOUS-SYSTEM REGENERATION
IDENTIFICATION OF AN INTERLEUKIN 2-LIKE SUBSTANCE AS A FACTOR CYTOTOXIC TO OLIGODENDROCYTES AND ASSOCIATED WITH CENTRAL-NERVOUS-SYSTEM REGENERATION
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DOI：
10.1073/pnas.89.12.5442
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发表时间：
1992-06-15
影响因子：
11.1
通讯作者：
SCHWARTZ, M
中科院分区：
文献类型：
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作者：
EITAN, S;ZISLING, R;SCHWARTZ, M
成年哺乳动物中枢神经系统的轴突在损伤后不能自发再生，部分原因是少突胶质细胞的存在抑制了轴突的生长。在低等脊椎动物(如鱼类)中则不是这样，视神经的再生确实是自发发生的，并与对少突胶质细胞具有细胞毒性的因子的存在有关。本研究提供的证据表明，来源于鱼类视神经的物质对少突胶质细胞具有细胞毒性，是一种白细胞介素2样物质。
Axons of the central nervous system in adult mammals do not regenerate spontaneously after injury, partly because of the presence of oligodendrocytes that inhibit axonal growth. This is not the case in lower vertebrates (e.g., in fish), where regeneration of the optic nerve does occur spontaneously and has been correlated with the presence of factors cytotoxic to oligodendrocytes. The present study provides evidence that the substance originating from the fish optic nerves, which is cytotoxic to oligodendrocytes, is an interleukin 2-like substance.