In search of encephalitis etiologies: Diagnostic challenges in the California Encephalitis Project, 1998-2000
In search of encephalitis etiologies: Diagnostic challenges in the California Encephalitis Project, 1998-2000
复制标题
DOI：
10.1086/367841
复制
发表时间：
2003-03-15
影响因子：
11.8
通讯作者：
Anderson, LJ
中科院分区：
文献类型：
--
作者：
Glaser, CA;Gilliam, S;Anderson, LJ
加州脑炎项目于1998年6月启动，目的是确定加州脑炎的病因和临床和流行病学特征。在病毒和立克次体疾病实验室(加利福尼亚州里士满)进行了大于或等于13种病原体的检测，包括疱疹病毒、肠道病毒、虫媒病毒、巴尔通体、衣原体和肺炎支原体。为每个病例收集的流行病学和临床信息指导进一步检测。从1998年6月到2000年12月，334名符合我们脑炎病例定义的患者入选。确诊或疑似脑炎病毒病原体31例(9%)，细菌病原体9例(3%)，寄生虫2例(1%)。在41例(12%)中确定了可能的病因。32例(10%)为非感染性病因，11例(3%)为非脑炎感染。尽管进行了广泛的检测和评估，208例(62%)的病因仍未解释。
The California Encephalitis Project was initiated in June 1998 to identify the causes and characterize the clinical and epidemiologic features of encephalitis in California. Testing for greater than or equal to13 agents, including herpesviruses, enteroviruses, arboviruses, Bartonella species, Chlamydia species, and Mycoplasma pneumoniae, was performed at the Viral and Rickettsial Disease Laboratory (Richmond, California). Epidemiologic and clinical information collected for each case guided further testing. From June 1998 through December 2000, 334 patients who met our case definition of encephalitis were enrolled. A confirmed or probable viral agent of encephalitis was found in 31 cases (9%), a bacterial agent was found in 9 cases (3%), and a parasitic agent was found in 2 cases (1%). A possible etiology was identified in 41 cases (12%). A noninfectious etiology was identified in 32 cases (10%), and a nonencephalitis infection was identified in 11 (3%). Despite extensive testing and evaluation, the etiology of 208 cases (62%) remained unexplained.