Unilamellar vesicles obtained by simply mixing dioctadecyldimethylammonium chloride and bromide with water
Unilamellar vesicles obtained by simply mixing dioctadecyldimethylammonium chloride and bromide with water
复制标题
DOI：
10.1016/j.chemphyslip.2006.01.005
复制
发表时间：
2006-04-01
影响因子：
3.4
通讯作者：
Edwards, K
中科院分区：
文献类型：
--
作者：
Feitosa, E;Karlsson, G;Edwards, K
双十八烷基二甲基溴化铵和氯化铵（DODAX，X = Br-，Cl-）在水中的光学透明分散体可以通过简单地在低浓度（1 mM）和安全高于DODAX在水中的凝胶到液晶相转变温度（T-m大约为45-48摄氏度）的温度下混合两亲物来获得。在这些条件下，动态光散射表明，在室温下，分散体含有两个明确的大囊泡群，DODAB 的平均流体动力学半径 (RH) 分别为 80 和 337 nm，DODAC 的平均流体动力学半径 (RH) 为 69 和 247 nm。冷冻透射电子显微镜 (cryo-TEM) 显微照片显示 DODAX 囊泡是单层且多分散的，表观半径高达 800 nm。根据浊度和摩尔吸收系数的老化时间依赖性，囊泡稳定至少1个月。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Optically clear dispersions of dioctadecyldimethylammonium bromide and chloride (DODAX, X = Br-, Cl-) in water can be obtained by simply mixing the amphiphiles at low concentrations (I mM) and at a temperature safely above the gel to liquid crystalline phase transition temperature (T-m approximate to 45-48 degrees C) of DODAX in water. Under these conditions, dynamic light scattering shows that, at room temperature, the dispersions contain two well-defined populations of large vesicles with average hydrodynamic radii (RH) of 80 and 337 nm for DODAB and of 69 and 247 nm for DODAC. Cryo-transmission electron microscopy (cryo-TEM) micrographs show that DODAX vesicles are unilamellar and polydisperse with apparent radius up to 800 nm. The vesicles are stable for at least I month according to the ageing time-dependence of the turbidity and molar absorption coefficient. (c) 2006 Elsevier Ireland Ltd. All rights reserved.