Dose-response relationships between sedentary behaviour and the metabolic syndrome and its components
Dose-response relationships between sedentary behaviour and the metabolic syndrome and its components
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DOI：
10.1007/s00125-014-3453-z
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发表时间：
2015-03-01
期刊：
影响因子：
8.2
通讯作者：
Colbert, Lisa H.
中科院分区：
文献类型：
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作者：
Gennuso, Keith P.;Gangnon, Ronald E.;Colbert, Lisa H.
本研究旨在探讨久坐行为（SB）与代谢综合征（MS）及其各组分之间的关系，并按年龄、中等强度体力活动（MVPA）和性别进行分析。076名成人，年龄为18岁（平均值+/- SD = 43.8 +/- 19.5）。使用ActiGraph加速度计测量SB，佩戴1周，定义为< 100计数/min。使用成人治疗组III标准定义代谢综合征。自然三次样条逻辑回归模型用于估计符合代谢综合征及其组分标准的几率，通过每日SB总时间和SB中断。SB与年龄、性别和MVPA之间的统计学相互作用进行了探索。代谢综合征的患病率为19%，平均每日SB时间为8.1 +/- 2.8 h，每天90 +/- 25次中断。每日SB时间和代谢综合征之间的关系是线性的，其特征是每小时SB的OR为1.09（95%CI 1.01，1.18）。总SB与以下成分相关：高甘油三酯，低HDL-胆固醇和高空腹血糖。所有这三种关联都通过MVPA水平进行了修改。没有发现SB中断和代谢综合征之间的关系。似乎没有SB阈值代谢综合征的风险增加。因此，应努力维持低水平的SB总时间，从而降低代谢综合征的风险。
The aim of this study was to examine the relationship among sedentary behaviour (SB) and the metabolic syndrome and its components by age, moderate-to-vigorous physical activity (MVPA) and sex.A cross-sectional analysis was performed on 2003-2006 National Health and Nutrition Examination Survey data from 5,076 adults aged a parts per thousand yen18 years (mean +/- SD = 43.8 +/- 19.5). SB was measured using ActiGraph accelerometers worn for 1 week and defined as < 100 counts/min. Metabolic syndrome was defined using the Adult Treatment Panel III criteria. Natural cubic spline logistic regression models were used to estimate the odds of meeting criteria for the metabolic syndrome and its components by total daily SB time and breaks in SB. Statistical interactions between SB and age, sex and MVPA were explored.The prevalence of the metabolic syndrome was 19% and the average daily SB time was 8.1 +/- 2.8 h, with 90 +/- 25 breaks/day. The relationship between daily SB time and the metabolic syndrome was linear and characterised by an OR of 1.09 (95% CI 1.01, 1.18) for each hour of SB. Total SB was associated with the following components: high triacylglycerol, low HDL-cholesterol and high fasting glucose. All three associations were modified by MVPA level. No relationship between breaks in SB and the metabolic syndrome was found.There appears to be no SB threshold at which the risk of the metabolic syndrome is elevated. Therefore, an effort should be made to maintain low levels of total time spent in SB and so lessen the risk of the metabolic syndrome.