Prolonged melatonin administration decreases nocturnal blood pressure in women
Prolonged melatonin administration decreases nocturnal blood pressure in women
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DOI：
10.1016/j.amjhyper.2005.05.008
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发表时间：
2005-12-01
影响因子：
3.2
通讯作者：
Volpe, A
中科院分区：
文献类型：
--
作者：
Cagnacci, A;Cannoletta, M;Volpe, A
背景资料。夜间血压的下降与褪黑素的升高几乎是一致的，褪黑素可能具有扩张血管和降压的作用。在这项研究中，我们研究了夜间长期服用褪黑素是否会影响女性的血压昼夜节律。方法：采用随机双盲试验，18名女性，年龄47-63岁，血压正常(N=9)或已治疗的高血压(N=9)，睡前1小时服用褪黑素缓释片(3 Mg)或安慰剂，疗程为3周。然后，他们被交换到另一个治疗组，继续治疗3周。结果：与安慰剂相比，服用褪黑素对昼夜血压无影响，但在不改变心率的情况下显著降低夜间收缩压(-3.77+/-1.7 mm Hg，P=0.0423)、舒张压(-3.63+/-1.3 mm Hg，P=0.0153)和平均血压(-3.71+/-1.3 mm Hg，P=0.013)。这种作用与血压昼夜差异呈负相关。结论：这些数据表明，长期服用褪黑素可能会改善血压昼夜节律，特别是在夜间血压下降迟钝的女性。
Background. The nocturnal decline of blood pressure (BP) is almost coincident with the elevation of melatonin, which may exert vasodilatating and hypotensive effects. In this study we investigated whether prolonged nocturnal administration of melatonin could influence the daily rhythm of BP in women.Methods: in a randomized double-blind study, 18 women, 47 to 63 years of age and with normal BP (N = 9) or treated essential hypertension (N = 9), received a 3-week course of a slow-release melatonin pill (3 mg) or placebo 1 h before going to bed. They were then crossed over to the other treatment for another 3 weeks. In each woman ambulatory BP was recorded for 41 h at baseline at the end of each treatment period.Results: In comparison with placebo, melatonin administration did not influence diurnal BP but did significantly decrease nocturnal systolic (-3.77 +/- 1.7 mm Hg, P = .0423), diastolic (-3.63 +/- 1.3 mm Hg, P = .0153), and mean (-3.71 +/- 1.3 mm Hg, P = .013) BP without modifying heart rate. The effect was inversely related to the day-night difference in BP.Conclusions: These data indicate that prolonged administration of melatonin may improve the day-night rhythm of BP, particularly in women with a blunted nocturnal decline.