Expression and significance of vascular endothelial growth factor C from multiple specimen sources in esophageal squamous cell carcinoma
Expression and significance of vascular endothelial growth factor C from multiple specimen sources in esophageal squamous cell carcinoma
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DOI：
10.5301/jbm.2012.9767
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发表时间：
2012-10-01
影响因子：
2
通讯作者：
Zhang, Jin
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Zhang, Mingxin;Zhang, Jin
背景：食管鳞状细胞癌（ESCC）是一种常见的恶性肿瘤，预后极差。血管内皮生长因子C（VEGF-C）在血管生成和淋巴管生成中起重要作用。本研究旨在分析多种标本来源的食管鳞癌中VEGF-C的表达与临床病理特征及生存期的关系。材料与方法：采用不同方法检测48例食管鳞癌组织（tVEGF-C）、血清（sVEGF-C）和淋巴液（lVEGF-C）中VEGF-C的表达。tVEGF-C高表达与肿瘤分化程度、肿瘤深度、淋巴结转移、TNM分期及转移密切相关。sVEGF-C仅与淋巴结转移、TNM分期及转移有关。IVEGF-C表达与tVEGG-C表达结果相似，但与肿瘤深度无相关性;单因素分析（log-rank检验）显示，tVEGF-C、sVEGF-C和IVEGF-C高表达与总生存期缩短显著相关。VEGF-C高表达可能是食管鳞癌预后不良的重要因素。
Background: Esophageal squamous cell carcinoma (ESCC) is a common malignancy with a very poor prognosis. Vascular endothelial growth factor C (VEGF-C) plays an important role in angiogenesis and lymphangiogenesis. This study was designed to analyze the correlation of VEGF-C expression with clinicopathological features and survival in multiple specimen sources from patients with ESCC.Material and methods: The expression of VEGF-C in tissues (tVEGF-C), serum (sVEGF-C), and lymph fluid (lVEGF-C) from 48 patients with ESCC was detected by different methods.Results: There were significant correlations between a high level of tVEGF-C expression and tumor differentiation, tumor depth, lymph node metastasis, TNM stage and metastasis. sVEGF-C was only significantly related to lymph node metastasis, TNM stage and metastasis. The results of lVEGF-C expression were similar to those of tVEGG-C expression, but no relationship to tumor depth was found. High expression levels of tVEGF-C, sVEGF-C and lVEGF-C were significantly associated with shorter overall survival times in univariate analysis (log-rank test).Conclusions: The expression of VEGF-C in multiple specimen sources from patients with ESCC was associated with certain clinicopathological parameters. High expression of VEGF-C may be an important factor related to a poor prognosis of ESCC.