Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
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DOI：
10.3389/fimmu.2020.00379
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发表时间：
2020-02-28
影响因子：
7.3
通讯作者：
Shimosato, Takeshi
中科院分区：
文献类型：
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作者：
Ogita, Tasuku;Yamamoto, Yoshinari;Shimosato, Takeshi
据报道，在人类粪便中发现的细菌Flavonifractor lastii（FP）参与了肠道中的儿茶素代谢，但这种细菌对免疫功能的影响尚不清楚。我们评估了口服FP对卵清蛋白（OVA）致敏小鼠免疫应答的影响。我们证明FP治疗抑制了OVA致敏小鼠脾细胞中的白细胞介素（IL）-4和OVA特异性IgE的产生。此外，口服FP增加了CD 4（+）CD 25（+）T细胞和CD 103（+）CD 11 c（+）DC。在FP组动物中，肠系膜淋巴结（MLN）中FP的比例增加，盲肠中脱铁杆菌的比例也增加。FP的口服给药可通过掺入MLN和/或通过诱导肠道微生物群的变化来抑制Th 2免疫应答。因此，FP可用于减轻抗原诱导的Th 2免疫应答。
The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported to participate in catechin metabolism in the gut, but this bacterium's effects on immune function are unclear. We assessed the effect of oral administration of FP on the immune response in ovalbumin (OVA) -sensitized mice. We demonstrated that the FP treatment suppressed interleukin (IL)-4 in splenocytes and OVA-specific IgE production in serum from OVA-sensitized mice. Moreover, oral administration of FP augmented CD4(+)CD25(+) T cells and CD103(+)CD11c(+) DCs. In animals of the FP group, the proportion of FP was increased in the mesenteric lymph nodes (MLNs), as was the proportion of Deferribacteres in the cecum. Oral administration of FP may inhibit the Th2 immune response by incorporation into the MLNs and/or by inducing changes in the gut microbiota. Thus, FP may be useful in alleviating antigen-induced Th2 immune responses.