The orbitofrontal cortex in methamphetamine addiction: involvement in fear
The orbitofrontal cortex in methamphetamine addiction: involvement in fear
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DOI：
10.1097/00001756-200212030-00017
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发表时间：
2002-12-03
期刊：
影响因子：
1.7
通讯作者：
Gur, RC
中科院分区：
文献类型：
--
作者：
Goldstein, RZ;Volkow, ND;Gur, RC
我们使用Tellegen的多维人格问卷（MPQ），伤害回避（恐惧）量表和约束超因子作为抑制控制的人格措施，并研究了它们与葡萄糖代谢的相关性在14个最近戒断甲基苯丙胺依赖的主题和22个对照主题的眶额回休息。较高的MPQ评分与甲基苯丙胺依赖受试者较高的相对眶额回代谢相关。比较受试者有负相关的趋势（两个受试者组回归线的一致性检验：F = 3.3，df = 2.32; p = 0.051）。这些结果表明，眶额皮层在抑制控制中的作用可以表现在稳定的人格倾向中，并进一步暗示该区域与药物成瘾的核心特征有关。
We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; p = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction.