Medicinal Chemistry of Gold Anticancer Metallodrugs
Medicinal Chemistry of Gold Anticancer Metallodrugs
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DOI：
10.1515/9783110470734-007
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Ott, Ingo
中科院分区：
文献类型：
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作者：
Casini, Angela;Sun, Raymond Wai-Yin;Ott, Ingo
自古以来，黄金及其络合物就被用作治疗各种疾病的药物。在现代医学中，金药物已被应用于治疗类风湿性关节炎，但最近其他医学应用也成为无机药物化学的焦点。本章提供了一个非全面的概述在金抗癌药物领域的主要发展。金（I）和金（III）配合物作为抗肿瘤药物的令人兴奋的发现进行了总结，并讨论了其作用模式的相关方面。
Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold drugs have been applied for the treatment of rheumatoid arthritis, however, recently other medical applications have come into the focus of inorganic medicinal chemistry. This chapter provides a non-comprehensive overview of key developments in the field of gold anticancer drugs. Exciting findings on gold(I) and gold(III) complexes as antitumor agents are summarized together with a discussion of relevant aspects of their modes of action.