A network of protein-protein interactions in yeast
A network of protein-protein interactions in yeast
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DOI：
10.1038/82360
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发表时间：
2000-12-01
影响因子：
46.9
通讯作者：
Fields, S
中科院分区：
文献类型：
--
作者：
Schwikowski, B;Uetz, P;Fields, S
对2,709种已发表的酿酒酵母蛋白质之间的相互作用进行了全球分析，从而建立了1,548种蛋白质之间2,358种相互作用的单一大型网络。已知功能和细胞位置的蛋白质倾向于聚集在一起，63%的相互作用发生在具有共同功能分配的蛋白质之间，76%发生在同一亚细胞区室中的蛋白质之间。可能的功能可以分配给蛋白质的基础上，其相互作用的伙伴的已知功能。这种方法正确预测了72%的1，393个特征蛋白质的功能类别，至少有一个已知功能的伴侣，并已被应用于预测364个以前未表征的蛋白质的功能。
A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63% of the interactions occurring between proteins with a common functional assignment and 76% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.