The bone marrow niche for haematopoietic stem cells.
The bone marrow niche for haematopoietic stem cells.
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DOI：
10.1038/nature12984
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发表时间：
2014-01-16
期刊：
影响因子：
64.8
通讯作者：
Scadden DT
中科院分区：
文献类型：
--
作者：
Morrison SJ;Scadden DT
小生境是维持和调节干细胞的局部组织微环境。造血为理解哺乳动物干细胞及其生态位提供了一个范例，但造血干细胞（HSC）生态位仍然没有完全定义，并受到竞争模型的困扰。在这里，我们回顾进展阐明的位置和细胞成分的造血干细胞龛在骨髓中。小生境位于血管周围，部分由间充质基质细胞和内皮细胞形成，通常但不总是位于骨小梁附近。悬而未决的问题涉及生态位的细胞复杂性，骨内膜的作用，以及血管周围微环境的功能异质性。
Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a paradigm for understanding mammalian stem cells and their niches, yet the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Here we review progress in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum, and functional heterogeneity among perivascular microenvironments.