Cortisol awakening response in late pregnancy in women with previous or ongoing depression
Cortisol awakening response in late pregnancy in women with previous or ongoing depression
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DOI：
10.1016/j.psyneuen.2013.08.007
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发表时间：
2013-12-01
影响因子：
3.7
通讯作者：
Sundstrom-Poromaa, Inger
中科院分区：
文献类型：
--
作者：
Hellgren, Charlotte;Akerud, Helena;Sundstrom-Poromaa, Inger
怀孕与基础皮质醇水平升高和下丘脑-垂体-肾上腺 (HPA) 轴反应性降低有关。皮质醇觉醒反应 (CAR) 是 HPA 轴反应性的衡量标准，据报道，在患有持续性抑郁症的患者和抑郁症缓解的个体中，皮质醇觉醒反应会增加。在这项研究中，我们调查了患有持续性或既往抑郁症的孕妇的 HPA 轴反应性。通过测量苏醒时以及苏醒后 15、30 和 45 分钟的唾液皮质醇来评估 CAR。根据结构化精神病学访谈和对怀孕期间抑郁症状的重复测量，134 名女性被纳入三组之一：从未抑郁 (n = 57)、当前怀孕前抑郁 (n = 39) 和当前怀孕期间抑郁 (n = 38)。鉴于先前发现非怀孕抑郁症受试者的 CAR 增加，我们假设持续或既往的抑郁症会导致更高的 CAR。与我们的假设相反，混合模型分析未能产生显着的组间差异。因此，我们的结果表明，从未抑郁过的孕妇和怀孕期间患有抑郁症的女性具有相似的皮质醇觉醒反应。此外，我们的研究结果表明，目前健康的女性在怀孕后期是否经历过抑郁发作，皮质醇觉醒反应没有差异。 (C) 2013 作者。由爱思唯尔有限公司出版。保留所有权利。
Pregnancy is associated with increased basal cortisol levels, and decreased hypothalamic-pituitary-adrenal (HPA) axis reactivity. The cortisol awakening response (CAR) is a measure of HPA-axis reactivity which has been reported to be increased in patients with ongoing depressive disorder and in individuals with remitted depression.In this study, we investigated HPA-axis reactivity in pregnant women with ongoing or previous depression. The CAR was assessed by measurement of salivary cortisol at awakening and 15, 30, and 45 min post-awakening. Based on structured psychiatric interviews and repeated measurements of depressive symptoms during pregnancy, 134 women were included in one of the three groups: never depressed (n = 57), depressed prior to the current pregnancy (n = 39), and depressed during the current pregnancy (n = 38). Given the prior findings of increased CAR in non-pregnant depressed subjects, we hypothesized that an ongoing or previous depression would result in a higher CAR.Contrary to our hypothesis, a mixed models analysis failed to yield significant group differences. Thus, our results suggest that never depressed pregnant women and women with depression during pregnancy have similar cortisol awakening responses. Furthermore, our findings suggest that the cortisol awakening response does not differ between currently healthy women with and without experience of a depressive episode during late pregnancy. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.