Relationship of RhoA signaling activity with ezrin expression and its significance in the prognosis for breast cancer patients
Relationship of RhoA signaling activity with ezrin expression and its significance in the prognosis for breast cancer patients
复制标题
DOI：
10.3760/cma.j.issn.0366-6999.20110738
复制
发表时间：
2013-01-20
影响因子：
6.1
通讯作者：
Li Zeng-huai
中科院分区：
文献类型：
--
作者：
Ma Li;Liu Yue-ping;Li Zeng-huai
我们最近报道RhoA可能作为ezrin的上游信号调节乳腺癌细胞的侵袭和转移。在这项研究中，我们研究了RhoA信号转导活性与ezrin在乳腺癌中的表达及其预后意义的乳腺癌患者的关系。方法石蜡切片的乳腺癌回顾性收集了2001年和2004年之间诊断的487例患者。结果Ezrin蛋白在487例浸润性乳腺癌中的表达率为15.2%。大多数（85.1%）ezrin过表达的肿瘤共表达磷酸化RhoA; 78.8%的肿瘤与磷酸化RhoA共过表达ezrin。患者的癌症表现出过度表达ezrin或表达磷酸化RhoA有较短的生存率。结论RhoA激活是重要的，在人类乳腺癌由于其上调ezrin，因此，代理人，靶向磷酸化RhoA可能是有用的ezrin过度表达的肿瘤的治疗。
Background We have recently reported that RhoA may regulate the invasion and metastasis of breast cancer cells as an upstream signal of ezrin in vitro. In this study, we examined the relationship of RhoA signaling activity with ezrin expression in breast cancer and its prognostic significance in patients with breast cancer.Methods Paraffin tumor sections of breast cancer were collected retrospectively from 487 patients diagnosed between 2001 and 2004. Immunohistochemical methods were used to detect the expression of RhoA, phosphorylated (activated) RhoA, and ezrin.Results Ezrin overexpression was detectable in 15.2% of 487 invasive breast cancers. The majority (85.1%) of ezrin-overexpressing tumors coexpressed phosphorylated RhoA; 78.8% of tumors with phosphorylated RhoA cooverexpressed ezrin. Patients whose cancers showed overexpression of ezrin or expression of phosphorylated RhoA had shorter survival rates.Conclusions RhoA activation is important in human breast cancer due to its upregulation of ezrin; thus, agents that target phosphorylated RhoA may be useful in the treatment of tumors with ezrin overexpression.