Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria.
Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria.
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DOI：
10.3390/ijms17050785
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发表时间：
2016-05-21
影响因子：
5.6
通讯作者：
Galdiero S
中科院分区：
文献类型：
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作者：
Falanga A;Lombardi L;Franci G;Vitiello M;Iovene MR;Morelli G;Galdiero M;Galdiero S
用于治疗细菌感染的抗生素的发现带来了细菌不再危害人类健康的想法。然而，细菌性疾病仍然是世界范围内的一种治疗方法，微生物产生耐药性的能力以及滥用抗生素是造成这种情况的主要原因;因此，耐药性迫使科学界寻找新的治疗方法。在这种情况下，抗菌肽（AMP）提供了一个很有前途的策略，对广泛的病原微生物，能够直接作为抗菌剂，但也是先天免疫系统的重要调节剂。本文综述了海洋抗菌肽作为抗菌活性分子的丰富来源。事实上，海洋在抗菌肽方面的探索很少，但它代表了一种资源，具有丰富的抗菌剂在恶劣的环境中发挥作用。对于AMP在医学领域中的应用，必须解决与其肽性质相关的限制，其通过环境pH、盐、蛋白酶或其他组分的存在而失活。因此，这些肽可以作为设计更有效和毒性更低的化合物的模板。
The discovery of antibiotics for the treatment of bacterial infections brought the idea that bacteria would no longer endanger human health. However, bacterial diseases still represent a worldwide treat. The ability of microorganisms to develop resistance, together with the indiscriminate use of antibiotics, is mainly responsible for this situation; thus, resistance has compelled the scientific community to search for novel therapeutics. In this scenario, antimicrobial peptides (AMPs) provide a promising strategy against a wide array of pathogenic microorganisms, being able to act directly as antimicrobial agents but also being important regulators of the innate immune system. This review is an attempt to explore marine AMPs as a rich source of molecules with antimicrobial activity. In fact, the sea is poorly explored in terms of AMPs, but it represents a resource with plentiful antibacterial agents performing their role in a harsh environment. For the application of AMPs in the medical field limitations correlated to their peptide nature, their inactivation by environmental pH, presence of salts, proteases, or other components have to be solved. Thus, these peptides may act as templates for the design of more potent and less toxic compounds.