Efficacy of chlorhexidine solution with fluoride varnishing in preventing enamel softening by Streptococcus mutans in an artificial mouth.
Efficacy of chlorhexidine solution with fluoride varnishing in preventing enamel softening by Streptococcus mutans in an artificial mouth.
复制标题
含氟化物清漆的氯己定溶液在防止人工口腔中变形链球菌引起的牙釉质软化方面的功效。
DOI：
10.1111/j.1600-0722.1994.tb01181.x
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
H. Luoma
中科院分区：
文献类型：
--
作者：
R. Sorvari;S. Spets;H. Luoma
为了研究氟化氯己定应用的牙釉质保护作用，用 0.2% 葡萄糖酸氯己定溶液、Duraphat 氟化物清漆或用上述两种药剂处理牛门牙片的唇表面，同时一组用蒸馏水处理，一组作为未处理的对照。此外，氯己定组和蒸馏水组使用了安慰剂清漆。 24小时后除去所有清漆。将牙釉质板成对安装在人造嘴中以形成近似接触。用添加了3%蔗糖的公共人工唾液池连续冲洗牙齿，并在第一天感染变形链球菌“Ingbritt”。每天更新唾液，37℃培养持续10天。在蒸馏水和安慰剂清漆处理组中发现的明显软化往往被氯己定所阻止，甚至被氟化物处理所阻止，而氯己定-氟化物处理则完全阻止牙釉质软化。唾液只在第一天被感染，每天都会更新，在实验结束时往往会变得更加酸化，显然是因为发酵微生物已经感染了模型的表面并在牙釉质上形成了牙菌斑状涂层。
For study of the enamel-protective effect of chlorhexidine-fluoride applications, the labial surfaces of pieces of bovine incisors were treated with 0.2% chlorhexidine gluconate solution, with Duraphat fluoride varnish, or with both of the above agents, while one group was treated with distilled water and one was left as an untreated control. Furthermore, a placebo varnish was used in the chlorhexidine- and distilled-water-treated groups; all the varnishes were removed after 24 h. The enamel slabs were mounted pairwise in an artificial mouth to form approximal contacts. The teeth were continuously rinsed with a common pool of artificial saliva to which was added 3% sucrose, and which was infected on the first day with Streptococcus mutans, "Ingbritt". The saliva was renewed daily and the incubation at 37 degrees C lasted for 10 days. The appreciable softening found in the distilled-water- and placebo-varnish-treated group tended to be prevented by the chlorhexidine and even more by the fluoride treatment, while the chlorhexidine-fluoride treatment prevented enamel softening completely. The saliva, infected only on the first day, and renewed daily, tended to become more acidified toward the end of the experimental period, obviously because the fermenting organisms had infected the surfaces of the model and formed plaque-like coatings on the enamel.