Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction
Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction
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DOI：
10.2174/0929867322666150420104727
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发表时间：
2015-01-01
影响因子：
4.1
通讯作者：
Tousoulis, Dimitris
中科院分区：
文献类型：
--
作者：
Pietri, Panagiota;Vlachopoulos, Charalambos;Tousoulis, Dimitris
在过去的几年里，大量的数据已经证明了低度炎症在动脉粥样硬化和心血管疾病的病理生理学中的关键作用。已经明确的是，在动脉粥样硬化疾病的慢性期作为底物或在急性期作为触发剂的炎症活化增加了心血管事件。考虑到高血压，炎症过程通过双向关系涉及其病理生理学，因为动脉高血压可增强炎症，反之亦然。高敏C反应蛋白等炎症标志物对高血压的发生率和高血压患者的临床结局均有预测价值。在本综述中，将报告动脉高血压和低度炎症之间的关联数据，并讨论这种关联的潜在病理生理学途径和临床意义。
Over the last years, ample data have demonstrated the pivotal role of low-grade inflammation in the pathophysiology of atherosclerosis and cardiovascular disease. It is well established that inflammatory activation, serving either as a substrate, in the chronic phase of atherosclerotic disease, or as a trigger, in the acute phase, increases cardiovascular events. Considering hypertension, the inflammatory process is implicated in its pathophysiology through a bidirectional relationship since arterial hypertension may enhance inflammation and vice versa. Inflammatory biomarkers such as high-sensitivity C-reactive protein, have shown predictive value for both the incidence of hypertension and the clinical outcomes in hypertensive patients. In the present review, data on the association between arterial hypertension and low-grade inflammation will be reported and potential pathophysiological pathways and clinical implications underlying this association will be discussed.