Long-term soy isoflavone supplementation and cognition in women A randomized, controlled trial
Long-term soy isoflavone supplementation and cognition in women A randomized, controlled trial
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DOI：
10.1212/wnl.0b013e318258f822
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发表时间：
2012-06-01
期刊：
影响因子：
9.9
通讯作者：
Mack, W. J.
中科院分区：
文献类型：
--
作者：
Henderson, V. W.;St John, J. A.;Mack, W. J.
目的：为了确定长期饮食中大豆异黄酮的认知影响，每日剂量与传统的亚洲dietes.Methods相当：在双盲妇女异黄酮大豆健康试验中，健康的绝经后妇女被随机分配接受每日25克富含大豆异黄酮的大豆蛋白（91 mg糖苷配基重量的异黄酮：52 mg染料木黄酮、36 mg大豆苷元和3 mg黄豆黄素）或乳蛋白匹配的安慰剂。在2.5年时，两组之间比较的主要认知终点是总体认知相对于基线的变化，这是14项神经心理学测试评分变化的加权和的复合。次要结果比较了认知因素和个体tests.Results的变化：共有350名年龄在45-92岁的健康绝经后妇女参加了这项试验，313名妇女的基线和终点认知测试数据被纳入意向治疗分析。两组的依从性均接近90%。总体认知较基线的变化无显著组间差异（安慰剂组平均标准化改善为0.42，安慰剂组为0.31;平均标准化差异为0.11，95%置信区间[CI] -0.13至0.35）。二次分析表明，在视觉记忆因素的改善更大，（平均标准化差异0.33，95%CI 0.06-0.60），但在其他3个认知因素或个体测试分数上没有显著的组间差异，在年轻绝经后妇女亚组内也没有显著差异。对于健康的绝经后妇女，长期饮食中补充大豆蛋白的剂量与传统的亚洲饮食相当，对整体认知没有影响，但可能改善视觉记忆。证据分类：这项研究提供了I类证据，证明长期膳食补充富含大豆蛋白的大豆蛋白并不能改善健康绝经后妇女的整体认知。神经病学（R）2012;78：1841-1848
Objective: To determine the cognitive effects of long-term dietary soy isoflavones in a daily dose comparable to that of traditional Asian diets.Methods: In the double-blind Women's Isoflavone Soy Health trial, healthy postmenopausal women were randomly allocated to receive daily 25 g of isoflavone-rich soy protein (91 mg of aglycone weight of isoflavones: 52 mg of genistein, 36 mg of daidzein, and 3 mg glycitein) or milk protein-matched placebo. The primary cognitive endpoint compared between groups at 2.5 years was change from baseline on global cognition, a composite of the weighted sum of 14 neuropsychological test score changes. Secondary outcomes compared changes in cognitive factors and individual tests.Results: A total of 350 healthy postmenopausal women aged 45-92 years enrolled in this trial; 313 women with baseline and endpoint cognitive test data were included in intention-to-treat analyses. Adherence in both groups was nearly 90%. There was no significant between-group difference on change from baseline in global cognition (mean standardized improvement of 0.42 in the isoflavone group and 0.31 in the placebo group; mean standardized difference 0.11, 95% confidence interval [CI] -0.13 to 0.35). Secondary analyses indicated greater improvement on a visual memory factor in the isoflavone group (mean standardized difference 0.33, 95% CI 0.06-0.60) but no significant between-group differences on 3 other cognitive factors or individual test scores, and no significant difference within a subgroup of younger postmenopausal women.Conclusion: For healthy postmenopausal women, long-term dietary soy isoflavone supplementation in a dose comparable to that of traditional Asian diets has no effect on global cognition but may improve visual memory.Classification of evidence: This study provides Class I evidence that long-term dietary supplementation with isoflavone-rich soy protein does not improve global cognition of healthy postmenopausal women. Neurology (R) 2012;78:1841-1848