Silica, alumina and clay catalyzed peptide bond formation:: Enhanced efficiency of alumina catalyst
Silica, alumina and clay catalyzed peptide bond formation:: Enhanced efficiency of alumina catalyst
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DOI：
10.1023/a:1006524703513
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发表时间：
1999-10-01
影响因子：
2
通讯作者：
Rode, BM
中科院分区：
文献类型：
--
作者：
Bujdák, J;Rode, BM
测试了粘土（锂蒙脱石）、二氧化硅和氧化铝在甘氨酸（Gly）、丙氨酸（Ala）、脯氨酸（Pro）、缬氨酸（Val）和亮氨酸（Leu）肽键形成反应中的催化效率。反应在 85 摄氏度下进行干燥/润湿（锂蒙脱石）和温度波动（二氧化硅和氧化铝）实验。氨基酸的反应性按 Gly > Ala > Pro 的顺序降低，近似于 Val，近似于 Leu。氧化铝的催化效率最高，它是所有研究的反应系统中唯一产生寡肽的催化剂。氧化铝上肽键的形成可能是由与工业化学中使用的一些氧化铝催化脱水反应相同的位点并通过相似的反应机制催化的。
Catalytic efficiencies of clay (hectorite), silica and alumina were tested in peptide bond formation reactions of glycine (Gly), alanine (Ala), proline (Pro), valine (Val) and leucine (Leu). The reactions were performed as drying/wetting (hectorite) and temperature fluctuation (silica and alumina) experiments at 85 degrees C. The reactivity of amino acids decreased in order Gly > Ala > Pro approximate to Val approximate to Leu. The highest catalytic efficiency was observed for alumina, the only catalyst producing oligopeptides in all investigated reaction systems. The peptide bond formation on alumina is probably catalyzed by the same sites and via similar reaction mechanisms as some alumina-catalyzed dehydration reactions used in industrial chemistry.