Glial cell morphological and density changes through the lifespan of rhesus macaques.
Glial cell morphological and density changes through the lifespan of rhesus macaques.
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DOI：
10.1016/j.bbi.2016.01.006
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
MacLean AG
中科院分区：
文献类型：
--
作者：
Robillard KN;Lee KM;Chiu KB;MacLean AG
衰老如何影响中枢神经系统（CNS）是一个非常感兴趣的领域。已知神经胶质形态影响神经元和免疫功能以及代谢和稳态平衡。胶质细胞（星形胶质细胞和小胶质细胞）的活化在发育和衰老期间的几个阶段发生。本研究分析了恒河猴整个生命周期中神经胶质形态和密度的变化，恒河猴在生理学和解剖学上与人类相似。我们观察到明显的增长，灰质星形胶质细胞的过程长度和过程的复杂性，从青少年到成年恒河猴成熟。这些变化不归因于细胞增大，因为它们不伴随着索马或突起体积的成比例变化。随着猕猴年龄的增长，白色物质小胶质细胞突起长度减少。衰老对灰质小胶质细胞密度有显著影响，与成年猕猴相比，老年猕猴的灰质小胶质细胞密度显著增加。总之，我们观察到随着猕猴年龄的增长，胶质细胞形态发生了显着变化，表明老年猕猴中星形胶质细胞活化，随后小胶质细胞密度增加。
How aging impacts the central nervous system (CNS) is an area of intense interest. Glial morphology is known to affect neuronal and immune function as well as metabolic and homeostatic balance. Activation of glia, both astrocytes and microglia, occurs at several stages during development and aging. The present study analyzed changes in glial morphology and density through the entire lifespan of Rhesus macaques, which are physiologically and anatomically similar to humans. We observed apparent increases in gray matter astrocytic process length and process complexity as rhesus macaques matured from juveniles through adulthood. These changes were not attributed to cell enlargement because they were not accompanied by proportional changes in soma or process volume. There was a decrease in white matter microglial process length as rhesus macaques aged. Aging was shown to have a significant effect on gray matter microglial density, with a significant increase in aged macaques compared with adults. Overall, we observed significant changes in glial morphology as macaques age indicative of astrocytic activation with subsequent increase in microglial density in aged macaques.