From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3
From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3
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DOI：
10.1007/s10863-017-9722-z
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发表时间：
2017-08-01
影响因子：
3
通讯作者：
Germain, Doris
中科院分区：
文献类型：
--
作者：
Kenny, Timothy C.;Germain, Doris
线粒体UPR （UPRmt）正迅速引起人们的关注。虽然大多数关于UPRmt的研究都集中在它在衰老中的作用，但新兴研究表明，UPRmt在癌症中也起着重要作用。此外，在哺乳动物细胞中，upmt的几个参与者在细胞器的维持中发挥了很好的作用。本综述的目的是强调UPRmt在当前文献中被忽视的方面，描述UPRmt在线粒体生物学中的特定角色，并强调在癌症中靶向UPRmt可能已经触手可及的有趣可能性。
The mitochondrial UPR (UPRmt) is rapidly gaining attention. While most studies on the UPRmt have focused on its role in aging, emerging studies suggest an important role of the UPRmt in cancer. Further, several of the players of the UPRmt in mammalian cells have well reported roles in the maintenance of the organelle. The goal of this review is to emphasize aspects of the UPRmt that have been overlooked in the current literature, describe the role of specific players of the UPRmt in the biology of the mitochondria and highlight the intriguing possibility that targeting the UPRmt in cancer may be already within reach.