The brain renin-angiotensin system: localization and general significance.
The brain renin-angiotensin system: localization and general significance.
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脑肾素-血管紧张素系统：定位和一般意义。
DOI：
10.1097/00005344-199219006-00010
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发表时间：
1992
影响因子：
3
通讯作者：
Ganten,D
中科院分区：
文献类型：
--
作者：
Bunnemann,B;Fuxe,K;Ganten,D
本文综述了大鼠脑内存在的肾素-血管紧张素系统成分的现有资料。血管紧张素原mRNA、mas原癌基因mRNA、血管紧张素II（Ang II）和Ang II受体已通过原位杂交、免疫细胞化学和受体放射自显影在脑中定位。这些标记物被证明广泛分布在整个大脑中，不仅限于与心血管控制相关的区域，而且还存在于功能不同的区域，这也表明了血管紧张素肽的其他功能。这些成分的分布模式与血管紧张素原、肾素、血管紧张素转换酶和血管紧张素片段的分布数据相关，这些数据显示了大量的拓扑错配。使用“体积传输”的模型，这些失配的可能的解释提出。在这方面，血管紧张素片段和mas原癌基因在脑肾素-血管紧张素系统的功能可能参与也进行了讨论，表明这个中央调节系统的复杂性不断增加。
This report summarizes the present data about the existence of components of the renin-angiotensin system in the rat brain. Angiotensinogen mRNA, mas protooncogene mRNA, angiotensin II (Ang II), and Ang II receptors have been mapped in the brain by using in situ hybridization, immunocytochemistry, and receptor autoradiography. These markers turned out to be widely distributed throughout the brain and to be not only restricted to areas related to cardiovascular control, but also to be present in functionally different areas, suggesting also other functions of angiotensin peptides. The distribution patterns of these components were correlated with data on the distribution of angiotensinogen, renin, angiotensin converting enzyme, and angiotensin fragments that revealed substantial topological mismatches. Using the model of “volume transmission,” possible explanations for these mismatches are proposed. In this regard, a possible involvement of angiotensin fragments and the mas proto-oncogene in the functioning of the brain renin-angiotensin system is also discussed, demonstrating the increasing complexity of this central regulatory system.