Imaging unconditioned fear response with manganese-enhanced MRI (MEMRI)
Imaging unconditioned fear response with manganese-enhanced MRI (MEMRI)
复制标题
DOI：
10.1016/j.neuroimage.2007.05.001
复制
发表时间：
2007-08-01
期刊：
影响因子：
5.7
通讯作者：
King, Jean A.
中科院分区：
文献类型：
--
作者：
Chen, Wei;Tenney, Jeff;King, Jean A.
最近使用锰增强MRI（MEMRI）来评估自主神经和躯体感觉范式中涉及的神经回路已经很有希望。目前的研究讨论了利用这种技术来评估更复杂的认知和情感过程的可行性。由于嗅觉线索是特别突出的动物，我们利用无味的空气，新的/唤起和新的/恐惧诱导气味，以评估神经回路subserving新奇和无条件的恐惧。目前的成像数据清楚地表明，动物没有事先暴露于威胁诱导的情绪刺激选择性地激活无条件的恐惧神经元通路，特别是杏仁核和下丘脑激活。而动物暴露于新的/引起恐惧的气味相比，表现出增强的吸收扣带和前额叶皮层。此外，正如预期的那样，海马显示出显着增强锰对比后，新奇的曝光。因此，本研究支持MEMRI在探索与认知和情绪相关的高度相关的复杂神经回路中的有效性。(c)2007年爱思唯尔公司All rights reserved.
Recent use of manganese-enhanced MRI (MEMRI) to assess the neural circuitry involved in autonomic and somatosensory paradigms has been promising. The current study addresses the feasibility of utilizing this technique to assess more complex cognitive and emotional processes. Since olfactory cues are particularly salient to animals, we utilized odorless air, novel/arousing and novel/fear-inducing scents to assess the neural circuitry sub-serving novelty and unconditioned fear. The present imaging data clearly indicate that animals with no prior exposure to a threat-inducing emotional stimulus selectively activated the unconditional fear neuronal pathway, specifically with heightened amygdala and hypothalamic activation. While animals exposed to the novel/arousing compared to fear-inducing odor demonstrated enhanced uptake in the cingulated and prefrontal cortices. In addition, as expected the hippocampus showed significantly enhanced manganese contrast after novelty exposure. Therefore the current study support the validity of MEMRI in the exploration of highly relevant complex neural circuitries associated with cognition and emotion. (c) 2007 Elsevier Inc. All rights reserved.