COLONIZATION OF THE ORAL CAVITY OF MICE BY AN UNIDENTIFIED STREPTOCOCCUS
COLONIZATION OF THE ORAL CAVITY OF MICE BY AN UNIDENTIFIED STREPTOCOCCUS
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DOI：
10.1111/j.1399-302x.1995.tb00138.x
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发表时间：
1995-06-01
影响因子：
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通讯作者：
LAVOIE, MC
中科院分区：
文献类型：
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作者：
MARCOTTE, H;RODRIGUE, L;LAVOIE, MC
在研究小鼠口腔细菌生物群时，我们观察到一种未鉴定的链球菌（TG），最终成为我们动物设施中所有其他小鼠口腔的优势种。我们发现该菌株是杰克逊实验室小鼠的固有菌株，但在Charles River实验室的动物中不存在。TG也从人工污染的BALB/c小鼠传播到其他4个小鼠品系的口腔。链球菌TG刺激人工污染的Charles River BALB/c小鼠的分泌和全身免疫系统，但没有引起临床症状。对TG抗体水平的增加并不能阻止其在这些小鼠中的定殖和持续存在。在来自杰克逊实验室的小鼠中，对TG的分泌和全身免疫应答显著降低。在体外，链球菌属TG抑制小鼠口腔乳酸杆菌和葡萄球菌，可能是由于过氧化氢的生产。
While studying the oral bacterial biota of mice, we observed an unidentified streptococcus (TG) that eventually became the dominant species of the oral cavities of all other mice in our animal facility. We found that the strain is indigenous to Jackson Laboratory mice but is absent in animals from Charles River Laboratories. TG was also transmitted from artificially contaminated BALB/c mice to the oral cavities of 4 other mouse strains. Streptococcus sp. TG stimulated the secretory and systemic immune systems of artificially contaminated Charles River BALB/c mice but did not provoke clinical symptoms. The increase in antibody level to TG did not prevent its colonization and persistence in these mice, In mice from Jackson Laboratory, the secretory and systemic immune response to TG was significantly lower. In vitro, Streptococcus sp. TG inhibited murine oral lactobacilli and staphylococci, probably due to the production of hydrogen peroxide.