Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C-H bond functionalization of heteroarenes: are nanoparticles a moribund form of Pd or an active catalytic species?
Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C-H bond functionalization of heteroarenes: are nanoparticles a moribund form of Pd or an active catalytic species?
复制标题
DOI：
10.1016/j.tet.2014.06.002
复制
发表时间：
2014-09-09
期刊：
影响因子：
2.1
通讯作者：
Fairlamb, Ian J. S.
中科院分区：
文献类型：
--
作者：
Baumann, Christoph G.;De Ornellas, Sara;Fairlamb, Ian J. S.
对常用的C-H键功能化催化剂Pd(OAc)(2)催化的一系列杂芳烃(如吲哚、苯并恶唑、苯并噻唑、苯并咪唑和嘌呤衍生物)的C-H键官能化反应的研究表明，在工作催化剂条件下，可以迅速形成规整的Pd纳米颗粒(PdNPs)。包埋在聚合物基质(聚乙烯吡咯烷酮，PVP)中的PdNPs可以进行异地表征。独立合成的Pd(PVP)纳米粒子是具有催化活性的物种，在几个C-H键功能化反应中表现出与Pd(OAc)(2)相当的催化活性。在一系列反应中，Pd浓度是一个共同的变量，它可以与使用DMF、DMSO和乙酸等极性溶剂的工作催化条件下PdNPs的生长有关。(C)2014爱思唯尔有限公司。保留所有权利。
Examination of a series of C-H bond functionalization reactions of heteroarenes (e.g., indole, benzoxazole, benzthiazole, benzimidazole and purine derivatives) mediated by Pd(OAc)(2), a commonly used C-H bond functionalization catalyst, reveals that well-defined Pd nanoparticles (PdNPs) are rapidly formed under working catalyst conditions. The PdNPs can be characterized ex situ after entrapment in a polymer matrix (polyvinylpyrrolidinone, PVP). Independently synthesized Pd(PVP)NPs are catalytically competent species, exhibiting catalyst activity commensurate with Pd(OAc)(2) in several C-H bond functionalization reactions. Across a range of reactions, Pd concentration is a common variable, which can be linked to the propagation of PdNPs under working catalytic conditions using polar solvents like DMF, DMSO and acetic acid. (C) 2014 Elsevier Ltd. All rights reserved.