The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas
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DOI：
10.1006/cyto.2001.0947
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发表时间：
2001-10-21
期刊：
影响因子：
3.8
通讯作者：
Maeda, K
中科院分区：
文献类型：
--
作者：
Kabashima, H;Yoneda, M;Maeda, K
白细胞向炎症部位的浸润，如在人类根尖周围肉芽肿中观察到的，被认为是由趋化因子介导的。在这项研究中，我们通过免疫组织化学方法检测了从人类受试者获得的样本中趋化因子和趋化因子受体阳性细胞的存在。根尖周围肉芽肿中存在巨噬细胞趋化蛋白-1 （MCP-1）、巨噬细胞炎症蛋白(MIP)-1 α、MIP-10和ifn诱导蛋白10 （IP-10）产生细胞。此外，趋化因子受体CCR3-、CCR5-和cxcr3阳性细胞也存在。而临床健康牙周韧带无表达，作为阴性对照。我们的研究结果表明，这些趋化因子负责调节疾病的过程，如人类根尖牙周炎。(C) 2001学术出版社。
The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1 alpha, MIP-10 and IFN-inducible protein 10 (IP-10) producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis. (C) 2001 Academic Press.