Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats
Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats
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DOI：
10.1167/iovs.05-1213
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Schwartz, Michal
中科院分区：
文献类型：
--
作者：
Bakalash, Sharon;Rolls, Asya;Schwartz, Michal
目的。从天然化合物硫酸软骨素蛋白聚糖（CSPG）中提取的双糖（DS）最近被证明具有神经保护活性。作者检测了该化合物（CSPG-DS）保护视网膜神经节细胞（RGCs）免受眼压升高（IOP）引起的死亡的能力。通过使用慢性和急性IOP升高模型，作者检测了cpg - ds对成年（2个月大）、老年（10-12个月大）和免疫功能低下的Lewis大鼠RGC存活的影响。研究了全身、局部和口服给药途径。CSPG-DS保护RGCs免于iopo诱导的死亡。治疗在所有三种被检查的大鼠群体（正常成年大鼠、老年大鼠和免疫功能低下大鼠）和所有给药途径中均有效，可能部分通过其对小胶质细胞活性的控制。结果表明CSPG-DS治疗青光眼的潜力，特别是在疾病患病率高的老年人群中。
PURPOSE. A disaccharide (DS) derived from the naturally occurring compound chondroitin sulfate proteoglycan (CSPG) was recently shown to have neuroprotective activity. The authors examined the ability of this compound (CSPG-DS) to protect retinal ganglion cells (RGCs) from death caused by elevated intraocular pressure (IOP).METHODS. With the use of chronic and acute models of elevated IOP, the authors examined the effects of CSPG-DS on RGC survival in adult (similar to 2 months old), aged (10-12 months old), and immunocompromised Lewis rats. Systemic, topical, and oral routes of administration were examined.RESULTS. CSPG-DS protected RGCs from IOP-induced death. Treatment was effective in all three examined rat populations (normal adult, aged, and immunocompromised rats) and with all routes of administration, possibly in part through its control of microglial activity.CONCLUSIONS. Results point to the therapeutic potential of CSPG-DS for glaucoma, particularly in elderly populations for whom disease prevalence is high.