CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions
CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions
复制标题
DOI：
10.1111/j.1365-2249.1993.tb03377.x
复制
发表时间：
1993-05
影响因子：
4.6
通讯作者：
G. D. Ross;V. Vetvicka
中科院分区：
文献类型：
--
作者：
G. D. Ross;V. Vetvicka
C3受体CR 3在吞噬细胞（B和T细胞的次要亚群）上表达。和自然杀伤（NK）细胞。它作为粘附分子和介导多种配体（如细胞间粘附分子-1（ICAM-1）和固定的iC 3b）识别的膜受体具有重要功能。该受体能够经历活化事件，该活化事件调节其对各种配体的特异性和其介导吞噬作用或细胞外吞噬作用的能力。某些细菌表达碳水化合物或脂多糖（LPS），可以结合并激活CR 3，使受体呈现其激活状态。源自酵母酿酒酵母的可溶性β-葡聚糖是一种特别有效的CR 3刺激剂，并产生受体的活化状态，使中性粒细胞吞噬iC 3b包被的红细胞或NK细胞毒性iC 3b包被的肿瘤细胞，但通常对NK细胞具有抗性。
The C3 receptor CR3 is expressed on phagocytie cells, minor subsets of B and T eells. and natural killer (NK) cells. It has important functions both as an adhesion molecule and a membrane receptor mediating recognition of diverse ligands such as intercellular adhesion molecule‐1 (ICAM‐1) and fixed iC3b. The receptor is capable of undergoing an activation event that regulates both its specificity for various ligands and its ability to mediate phagocytosis or extracellular eytotoxieily. Certain bacteria express earbohydrates or lipopolysaccharidcs (LPS) that can bind to and activate CR3, allowing the receptor to assume its activated state. Soluble β‐glucan derived frotn the yeast Saccharomyces cerevisiae is a particularly potent stimulator of CR3, and produces an activated state of the receptor that permits neutrophil phagocytosis of iC3b‐coated erytbrocytes or NK cell eytotoxicity of iC3b‐coated tumour cells, tbat are normally resistant to NK cells.