Performance of blend sign in predicting hematoma expansion in intracerebral hemorrhage: A meta-analysis
Performance of blend sign in predicting hematoma expansion in intracerebral hemorrhage: A meta-analysis
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DOI：
10.1016/j.clineuro.2017.10.017
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发表时间：
2017-12-01
影响因子：
1.9
通讯作者：
You, Chao
中科院分区：
文献类型：
--
作者：
Yu, Zhiyuan;Zheng, Jun;You, Chao
目的：血肿扩大与脑出血（ICH）预后不良独立相关。混合征是非对比计算机断层扫描中血肿扩展的简单预测因素。然而，其预测血肿扩大的准确性在以往的研究中并不一致。本荟萃分析的目的是系统地评估混合征在预测ICH血肿扩大方面的表现。材料和方法：进行了系统的文献检索。纳入了关于混合征预测ICH血肿扩大准确性的原始研究。计算合并的灵敏度、特异性、阳性和阴性似然比。绘制了受试者工作特征曲线。结果：共纳入5篇文献，2248例患者。混合征预测血肿扩大的合并敏感性、特异性、阳性和阴性似然比分别为0.28、0.92、3.4和0.78。曲线下面积（AUC）为0.85。结论：本荟萃分析表明，混合征是一个有用的预测ICH血肿扩大的高特异性。混合征预测血肿扩大的准确性尚需进一步大样本研究验证。
Objectives: Hematoma expansion is independently associated with poor outcome in intracerebral hemorrhage (ICH). Blend sign is a simple predictor for hematoma expansion on non-contrast computed tomography. However, its accuracy for predicting hematoma expansion is inconsistent in previous studies. This meta-analysis is aimed to systematically assess the performance of blend sign in predicting hematoma expansion in ICH.Material and methods: A systematic literature search was conducted. Original studies about predictive accuracy of blend sign for hematoma expansion in ICH were included. Pooled sensitivity, specificity, positive and negative likelihood ratios were calculated. Summary receiver operating characteristics curve was constructed. Publication bias was assessed by Deeks' funnel plot asymmetry test.Results: A total of 5 studies with 2248 patients were included in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratios of blend sign for predicting hematoma expansion were 0.28, 0.92, 3.4 and 0.78, respectively. The area under the curve (AUC) was 0.85. No significant publication bias was found.Conclusion: This meta-analysis demonstrates that blend sign is a useful predictor with high specificity for hematoma expansion in ICH. Further studies with larger sample size are still necessary to verify the accuracy of blend sign for predicting hematoma expansion.