Disseminated Trichosporonosis:The First Case Report in China
Disseminated Trichosporonosis:The First Case Report in China
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发表时间：
2001-10
影响因子：
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通讯作者：
Rongya Yang;J. Ao;Wen-ling Wang;Dawei Li;Ruoyu Li
中科院分区：
文献类型：
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作者：
Rongya Yang;J. Ao;Wen-ling Wang;Dawei Li;Ruoyu Li
目的报道中国首例播散性毛磷病。方法对一名无明确基础疾病的20岁女性患者进行了一系列临床、组织病理学和真菌学研究。通过培养、生化试验和DNA测序鉴定了病原菌。结果感染性肉芽肿标本中有丰富的真菌孢子、酵母和菌丝。皮肤病变或结痂、肝脏、口腔假膜、阴道、鼻腔、尿液和粪便培养的真菌菌落相同。菌落呈乳白色至淡黄色，表面具皱纹，周围有菌丝。镜下可见大量的长方形节孢子，有或没有出芽的圆形或椭圆形孢子，以及分枝和隔生的细丝。分离得到的真菌被一致鉴定为朝日毛孢（Trichosporon asahii）。AS 2.2174)通过培养、生物化学和分子生物学测试。两性霉素B脂质体（Amphotec）联合氟康唑治疗后，患者病情明显好转。结论朝日肠杆菌引起的广泛而持久的全身损伤在国内外鲜有报道。两性霉素B联合氟康唑治疗是有效的。关键词：三磷酸腺苷；Trichosporonosis
Objective To report the first case of disseminated trichosporonosis in China. Methods A series of clinical,histopathologic,and mycologic studies were carried out in a 20 year-old-female patient,who had no definite underlying disease.The causative fungus was identified according to culture,biochemical test and DNA sequencing. Results Abundant fungal spores,yeasts and hyphae were shown in the specimens taken from infectious granulomas.The fungal colonies in the culture of skin lesions or crusts,liver, oral psedomembrane,vagina,nasal cavity,urine,and stool were the same.The colonies exhibited creamy white to yellowish in color,rugose on the surface,and hyphae at the periphery.Under microscopy,there were a lot of rectangular arthrospores,round or oval spores with or without buddings,as well as branched and septate filaments.The isolated fungus was unanimously identified as Trichosporon asahii(No. AS 2.2174) through culture,biochemistry and molecular biology tests.The patient's condition was improved obviously after the combination treatment of amphotericin B liposome(Amphotec) and fluconazole. Conclusion The extensive and lasting systemic impairments caused by T. asahii have scarcely been reported at home and abroad.Combination therapy with amphotericin B and fluconazole is effective. Key words: Trichosporon; Trichosporonosis