Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma.
Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma.
复制标题
术前白蛋白/球蛋白比值对喉鳞状细胞癌患者具有预测价值
DOI：
10.18632/oncotarget.18443
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发表时间：
2017-07-18
期刊：
影响因子：
--
通讯作者：
Yu JC
中科院分区：
文献类型：
--
作者：
Chen WZ;Yu ST;Xie R;Lv YX;Xu DB;Yu JC
本研究回顾性评价了术前白蛋白/球蛋白比值（AGR）对喉鳞状细胞癌（LSCC）的预测价值。本研究纳入了2005年1月至2010年12月南昌大学第二附属医院241例新诊断的喉鳞癌患者。总生存期（OS）的最佳AGR截止值确定为1.28。单因素生存分析显示，性别、低AGR、T分级、组织学分级和淋巴结转移是影响喉鳞癌患者OS的相关因素。此外，低AGR、T分级、淋巴结转移和组织学分级与喉鳞癌患者的无病生存率（DFS）相关。在多变量生存分析中，淋巴结转移和低AGR对OS和DFS仍有显著意义。我们的初步研究表明，低术前AGR可以作为一个有价值的和易于评估的血液为基础的指标，以预测喉鳞癌患者的预后。
This study evaluated the predictive value of the preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current study enrolled 241 newly diagnosed LSCC patients in the Second Affiliated Hospital of Nanchang University between January 2005 and December 2010. The optimal AGR cut-off value for overall survival (OS) was determined to be 1.28. Univariate survival analysis identified sex, low AGR, T classification, histological grade and nodal metastasis as factors associated with poor OS. Additionally, a low AGR, T classification, nodal metastasis, and histological grade were associated with poor disease-free survival (DFS) in LSCC patients. In multivariate survival analysis, nodal metastasis and a low AGR remained significant for OS and DFS. Our preliminary study revealed that low preoperative AGR could serve as a valuable and easily-assessed blood-based indicator to predict the prognosis of LSCC patients.