Could GABA, with a side of glycine, control glutamate receptors?
Could GABA, with a side of glycine, control glutamate receptors?
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DOI：
10.1111/ejn.13929
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Paladini CA
中科院分区：
文献类型：
--
作者：
Quraishi SA;Paladini CA
Dopamine neurons within the ventral tegmental area (VTA) synthesize diverse sources of inhibition and excitation to generate precise signals that underlie reward and aversion. Multiple lines of evidence point to the dominant influence of inhibition of dopamine neurons. The majority of synapses they receive are GABAergic (Bolam & Smith, 1990; Henny et al., 2012); they sustain persistent IPSPs in vivo (Grace & Bunney, 1985); and GABA receptor-mediated inhibition supersedes glutamatergic excitation to control firing pattern (Lobb et al., 2010). Antagonism of GABAergic inhibition in vivo triggers dopamine neurons to fire in a “bursty” mode (Paladini & Tepper, 1999), indicating that GABA tone maintains a tight balance on dopamine neuron excitability. Failure of inhibition is associated with dopamine hyperexcitabilty and pathological behaviors (for review see Morales & Margolis, 2017).In the current issue, Polter et al. isolate and differentiate two of the major sources of inhibition arriving at dopamine neurons: the GABA-releasing terminals from local GABA interneurons within the VTA, and from a region at the caudal tail of the VTA, termed the rostromedial tegmental nucleus (RMTg). The authors demonstrate that local VTA-and RMTg-originating terminals define distinct channels of inhibition that possess unique spatial distributions, synaptic properties, and capacities for long and short term plasticity (see also Simmons et al., 2017). Most intriguingly, the authors report two key properties of RMTg GABA-releasing terminals: 1) they fail to express a unique form of long term potentiation previously characterized at VTA GABAergic terminals (ie LTPGABA); and 2) they corelease the neurotransmitter glycine.
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影响因子：
4.7
作者：
Cabrera-Pastor, Andrea;Taoro-Gonzalez, Lucas;Felipo, Vicente
通讯作者：
Felipo, Vicente
DOI：
10.1124/jpet.117.244822
发表时间：
2018-04-01
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Vengeliene, Valentina;RoSSmanith, Martin;Spanagel, Rainer
通讯作者：
Spanagel, Rainer
影响因子：
64.8
作者：
Nugent, Fereshteh S.;Penick, Esther C.;Kauer, Julie A.
通讯作者：
Kauer, Julie A.
影响因子：
2.5
作者：
Lobb, Collin J.;Wilson, Charles J.;Paladini, Carlos A.
通讯作者：
Paladini, Carlos A.
影响因子：
2.9
作者：
GRACE, AA;BUNNEY, BS
通讯作者：
BUNNEY, BS