A new naphthoquinone and other antibacterial constituents from the roots of Xanthium sibiricum
A new naphthoquinone and other antibacterial constituents from the roots of Xanthium sibiricum
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苍耳根中的新萘醌和其他抗菌成分
DOI：
10.1080/14786419.2014.985678
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发表时间：
2015-04-18
影响因子：
2.2
通讯作者：
Chen, Guang-Ying
中科院分区：
文献类型：
--
作者：
Chen, Wen-Hao;Liu, Wen-Jie;Chen, Guang-Ying
重新研究西伯利亚苍耳根的化学成分，分离出一种新的萘醌 (1) 以及 13 种已知化合物 (2-14)。通过使用光谱分析（包括 HR-ESI-MS、1D 和 2D NMR）并将其 NMR 数据与相关化合物的 NMR 数据进行比较，阐明了它们的结构。化合物1对大肠杆菌、枯草芽孢杆菌、四联微球菌和金黄色葡萄球菌具有中等的抗菌活性，化合物6和12对大肠杆菌的抗菌活性强于阳性对照环丙沙星，最低抑菌浓度分别为0.17和0.35μg/mL。
Reinvestigating the chemical constituents of the roots of Xanthium sibiricum led to the isolation of a new naphthoquinone (1), together with 13 known compounds (2-14). Their structures were elucidated by using spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR, and by comparing their NMR data with those of related compounds. Compound 1 showed moderate antibacterial activity against Escherichia coli, Bacillus subtilis, Micrococcus tetragenus and Staphylococcus aureus, while 6 and 12 showed stronger antibacterial activity than the positive control ciprofloxacin against E. coli, with minimum inhibitory concentration values of 0.17 and 0.35 mu g/mL, respectively.