Avoidable burden of disease: conceptual and methodological issues in substance abuse epidemiology
Avoidable burden of disease: conceptual and methodological issues in substance abuse epidemiology
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DOI：
10.1002/mpr.199
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Gmel, Gerhard
中科院分区：
文献类型：
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作者：
Rehm, Juergen;Taylor, Benjamin;Gmel, Gerhard
确定可避免的疾病负担中可归因于药物使用的比例对于政策制定和干预措施的实施都很重要。目前的流行病学理论原则上提供了一种估计可避免的疾病负担的方法，现有的统计工具可以提供初步的粗略估计。本文所述的方法，其统计程序，举例说明，以估计可避免的烟草相关疾病在加拿大的负担。然而，需要进一步努力在方法细节方面找到解决办法，即暴露计量、风险因素的多维性、暴露分布随时间变化的估计，以及估计多个终点随时间变化的多重暴露的风险关系（因果网）。开始改进方法以获得更好的起点来估计可避免的疾病负担的动力是显而易见的，应该贯彻下去，以便通过循证政策和干预措施看到真实的变化。版权所有（c）2006约翰威利父子有限公司。
Determining the proportion of avoidable disease burden attributable to substance use is important for both policy development and intervention implementation. Current epidemiological theory has in principle provided a method to estimate avoidable burden of disease and the available statistical tools can provide first rough estimates. The method described in this paper, and its statistical procedures, are exemplified to estimate avoidable burden of tobacco-related disease in Canada. However, further effort is needed to find solutions in the methodological details, namely exposure measurement, risk factor multidimensionality, estimation of changes in exposure distribution over time, and estimation of risk relationships from multiple exposures changing over time with multiple endpoints (causal webs). The impetus to begin refining methods to obtain better starting points for estimating avoidable burden of disease is obvious and should be carried through in order to see real changes through evidence-based policy and intervention. Copyright (c) 2006 John Wiley & Sons, Ltd.