MR-Guided Focused Ultrasound: A New Generation Treatment of Parkinson's Disease, Essential Tremor and Neuropathic Pain
MR-Guided Focused Ultrasound: A New Generation Treatment of Parkinson's Disease, Essential Tremor and Neuropathic Pain
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DOI：
10.15274/nrj-2014-10033
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发表时间：
2014-05-01
影响因子：
1.7
通讯作者：
Pierzchala, Krystyna Barbara
中科院分区：
文献类型：
--
作者：
Dobrakowski, Pawel Piotr;Machowska-Majchrzak, Agnieszka Kamila;Pierzchala, Krystyna Barbara
高强度聚焦超声（HIFU）的应用是目前许多实验和临床试验的主题。高强度聚焦超声（HIFU）与磁共振成像（MRI）引导相结合，被称为磁共振引导聚焦超声（MRgFUS），似乎特别有希望消融位于大脑深处的组织。该方法可以作为介入神经病学的开端和神经外科的重要替代方法。迄今为止进行的研究表明，该方法在慢性病和急诊病例中均有效。该方法的安全性和有效性已在帕金森病和原发性震颤以及神经性疼痛中观察到。手术不需要麻醉。不使用电离辐射，没有累积剂量的风险。这些优势可能导致并发症发生率低，并为进一步开发MRgFUS提供医学依据。
The application of high intense focused ultrasound (HIFU) is currently the subject of many experimental and clinical trials. The combination of HIFU with MRI guidance known as MR-guided focused ultrasound (MRgFUS) appears to be particularly promising to ablate tissues located deep in the brain. The method can be the beginning of interventional neurology and an important alternative to neurosurgery. Studies conducted to date show the effectiveness of the method both in chronic diseases and in emergency cases. The safety and effectiveness of this method have been observed in parkinsonian and essential tremor as well as in neuropathic pain. The procedure does not require anaesthesia. Ionizing radiation is not used and there is no risk of cumulative dose. Such advantages may result in low complication rates and medical justification for further development of MRgFUS.