Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
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DOI：
10.1128/msystems.00105-19
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发表时间：
2019-05-01
期刊：
影响因子：
6.4
通讯作者：
Barr, Jeremy J.
中科院分区：
文献类型：
--
作者：
Barr, Jeremy J.
噬菌体、人类肠道的上皮细胞层和细菌共生体之间的三方共生可能在肠道微生物组的功能中发挥重要且未被认识的作用。传统上，肠道内的细菌被认为只与它们的细菌宿主相互作用，从而促进与上皮细胞层的间接相互作用，然而越来越多的文献证明了细菌直接与真核细胞、器官和身体系统相互作用的令人惊讶的和多样的方式。噬菌体可以粘附于粘膜表面，结合并转胞吞上皮细胞，并将蛋白质和核酸直接递送至真核细胞。这些相互作用可以建立正反馈回路，从而选择肠道中的细菌宿主及其噬菌体共生体。我实验室的成员正在努力扩大我们对噬菌体-真核生物相互作用的认识，并重新定义人体内三方共生的概念。
Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to facilitate indirect interactions with the epithelial cell layers, and yet a growing body of literature is demonstrating the surprising and diverse ways in which phages directly interact with the eukaryotic cells, organs, and systems of the body. Phages can adhere to mucosal surfaces, bind and transcytose epithelial cells, and deliver proteins and nucleic acids to eukaryotic cells directly. These interactions could establish positive-feedback loops leading to the selection of bacterial hosts and their phage symbionts in the gut. The members of my laboratory are working to expand our knowledge on the phage-eukaryote interactions and to redefine the concept of tripartite symbioses within the human body.