The significance of tumor-associated neutrophil density in uterine cervical cancer treated with definitive radiotherapy
The significance of tumor-associated neutrophil density in uterine cervical cancer treated with definitive radiotherapy
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DOI：
10.1016/j.ygyno.2017.02.009
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发表时间：
2017-06-01
影响因子：
4.7
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
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作者：
Matsumoto, Yuri;Mabuchi, Seiji;Kimura, Tadashi
Objective.本研究的目的是探讨肿瘤相关中性粒细胞（TAN）密度在接受确定性放疗的宫颈癌患者中的预后意义。收集1996年1月至2011年12月期间接受确定性放疗的FIGO IB-IVA期宫颈癌患者的基线特征和结局数据。使用初次诊断时获得的活检样本，通过免疫组织化学评估患者宫颈肿瘤中CD 66 b的表达水平。通过单因素和多因素分析，评估肿瘤内TAN密度与患者各种临床病理特征以及无进展生存期（PFS）之间的关系。250例宫颈癌组织中有209例（83.6%）CD 66 b阳性细胞（TAN）。TAN密度与较短的PFS显著相关。多变量分析发现TAN数量增加，（风险比[HR]：4.95; 95%置信区间[CI]：2.51-10.7; p < 0.0001），FIGO IVB期疾病（HR：2.64; 95% CI：1.38-5.01; p = 0.01），非鳞状细胞癌（SCC）组织学（HR：2.50; 95% CI：123-4.64; p = 0.01），肿瘤较大（HR：1.58; 95% CI：1.03-2.40; p = 0.04），盆腔淋巴结转移（HR：2.24; 95%CI：1.48-3.38; p = 0.0001）作为短PFS的独立预后因素。肿瘤内TAN密度是接受确定性放疗的宫颈癌患者PFS较短的独立预后因素。(C)2017爱思唯尔公司All rights reserved.
Objective. The aim of this study was to investigate the prognostic significance of tumor-associated neutrophil (TAN) density in cervical cancer patients that were treated with definitive radiotherapy.Methods. The baseline characteristics and outcome data of FIGO stages IB-IVA cervical cancer patients who were treated with definitive radiotherapy between January 1996 and December 2011 were collected. Using biopsy samples obtained at the time of the initial diagnosis, the expression levels of CD66b in the patients' cervical tumors were evaluated by immunohistochemistry. Univariate and multivariate analyses were performed to evaluate the relationships between intratumoral TAN density and various clinicopathological features as well as progression-free survival (PFS) in these patients.Results. The CD66b-positive cells (TAN) were observed in 209 (83.6%) of 250 cervical cancer specimens. The TAN density was significantly associated with shorter PFS. Multivariate analysis identified an increased number of TAN (hazard ratio [HR]: 4.95; 95% confidence interval [CI]: 2.51-10.7; p < 0.0001), FIGO stage IVB disease (HR: 2.64; 95% CI: 1.38-5.01; p = 0.01), non-squamous cell carcinoma (SCC) histology (HR: 2.50; 95% CI: 123-4.64; p = 0.01), larger tumors (HR: 1.58; 95% CI: 1.03-2.40; p = 0.04), and pelvic lymph node metastasis (HR: 2.24; 95% CI: 1.48-3.38; p = 0.0001) as independent prognostic factors for short PFS.Conclusion. Intratumoral TAN density is an independent prognostic factor for short PFS in cervical cancer patients treated with definitive radiotherapy. (C) 2017 Elsevier Inc. All rights reserved.