Defective neutrophil and lymphocyte function in leucocyte adhesion deficiency
Defective neutrophil and lymphocyte function in leucocyte adhesion deficiency
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白细胞粘附缺陷导致中性粒细胞和淋巴细胞功能缺陷
DOI：
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发表时间：
1991
影响因子：
4.6
通讯作者：
J. Lawton
中科院分区：
文献类型：
--
作者：
Y. Lau;L. Low;B. Jones;J. Lawton
We report a Chinese girl with the moderate phenotype of leucocyte adhesion deficiency (LAD), presenting with persistent omphalitis and recurrent soft tissue infections. She had subnormal adhesion‐dependent neutrophil functions, such as chemotaxis and chemiluminescence response to a particulate stimulant (opsonised zymosan). Despite her adequate humoral response to documented herpes simplex virus type 1, parainfluenza type 2 and adenovirus infection in vivo. there was marked impairment in the generation of plaque‐forming cells (PFC) driven by pokeweed mitogen (PWM) in vitro. IgM PFC were less severely affected than IgG and IgA PFC, probably because IgM production is less dependent on T cell help than IgA and IgG production. The patient's B cells and accessory cells had reduced function compared with the control subsets, while helper function of her CD4+ cells was virtually absent in the PWM‐driven PFC assay. She also had marked defect in natural killer cell activity. The proliferation of her lymphocytes was normal to several plant Iectins, including phytohaemagglutinin, concanavalin A and PWM, but markedly defective to OKT3.
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原始 T 细胞和记忆 T 细胞的激活要求不同。
DOI：
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发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Byrne,JA;Butler,JL;Cooper,MD
通讯作者：
Cooper,MD
影响因子：
6.4
作者：
ANDERSON, DC;SCHMALSTEIG, FC;SPRINGER, TA
通讯作者：
SPRINGER, TA
遗传性淋巴细胞功能相关抗原 1 缺陷：与 LFA-1 表达异常相关的细胞毒性和增殖异常。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Krensky,AM;Mentzer,SJ;Clayberger,C;Anderson,DC;Schmalstieg,FC;Burakoff,SJ;Springer,TA
通讯作者：
Springer,TA
DOI：
10.1097/00006454-198906000-00025
发表时间：
1989-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
R. Ezekowitz;M. Dinauer;H. Jaffe;S. Orkin;P. Newburger
通讯作者：
R. Ezekowitz;M. Dinauer;H. Jaffe;S. Orkin;P. Newburger
通过逆转录病毒介导的基因转移纠正 CD18 缺陷淋巴细胞。
DOI：
10.1126/science.1972597
发表时间：
1990
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Wilson,JM;Ping,AJ;Krauss,JC;Mayo-Bond,L;Rogers,CE;Anderson,DC;Todd,RF
通讯作者：
Todd,RF