Intercellular Junction Assembly, Dynamics, and Homeostasis
Intercellular Junction Assembly, Dynamics, and Homeostasis
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DOI：
10.1101/cshperspect.a000125
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发表时间：
2010-02-01
影响因子：
7.2
通讯作者：
Godsel, L. M.
中科院分区：
文献类型：
--
作者：
Green, Kathleen J.;Getsios, Spiro;Godsel, L. M.
细胞间锚定连接是质膜的高度特化区域，其中相对细胞上的跨膜粘附分子钙粘蛋白家族的成员通过其胞外结构域相互作用，并通过其细胞质结构域充当组织细胞骨架锚和重塑剂的平台。在这里，我们重点关注所谓的“锚定”或“粘附”连接的组装——粘附连接（AJ）和桥粒（DSM），它们分别与肌动蛋白和中间丝相关。我们将研究 AJ 和 DSM 的组装和功能如何在胚胎发生过程中以及在成体细胞和组织中密切相关，在某些情况下甚至形成专门的“混合”连接。我们将探索驱动组装和重塑的信号和运输机制，以及这些机制如何在人类疾病中发挥作用。
Intercellular anchoring junctions are highly specialized regions of the plasma membrane where members of the cadherin family of transmembrane adhesion molecules on opposing cells interact through their extracellular domains, and through their cytoplasmic domains serve as a platform for organizing cytoskeletal anchors and remodelers. Here we focus on assembly of so-called "anchoring" or "adhering" junctions-adherens junctions (AJs) and desmosomes (DSMs), which associate with actin and intermediate filaments, respectively. We will examine how the assembly and function of AJs and DSMs are intimately connected during embryogenesis and in adult cells and tissues, and in some cases even form specialized "mixed" junctions. We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease.