Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005
Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005
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DOI：
10.1186/1743-422x-7-127
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发表时间：
2010-06-14
期刊：
影响因子：
4.8
通讯作者：
Jeong, Young Eui
中科院分区：
文献类型：
--
作者：
Yun, Seok-Min;Cho, Jung Eun;Jeong, Young Eui
我们对1983-2005年在韩国分离的17株日本脑炎病毒（JEV）的包膜（E）基因进行了测序，并与先前报道的毒株进行了比较。我们的研究结果表明，显着的遗传稳定性的E基因序列在韩国的JEV株。来自10个韩国菌株的5对E基因序列是相同的，尽管存在地理差异和最长5年的时间跨度。与其他亚洲毒株的序列比较显示，韩国毒株与来自中国、日本和越南的毒株密切相关。在1993年之前，基因型3菌株在韩国占主导地位，当时首次分离出基因型1菌株K93 A07。这两种基因型在1994年被同时检测到，但从那时起，韩国只分离出基因型1。因此，基因型的变化发生根据隔离的年份，而不是地理来源。
We sequenced the envelope (E) gene of 17 strains of the Japanese encephalitis virus (JEV) isolated in South Korea in 1983-2005 and compared the sequences with those from previously reported strains. Our results show the remarkable genetic stability of the E gene sequence in Korean JEV strains. Five pairs of E gene sequences from 10 Korean strains were identical, despite geographical differences and a maximum five-year time span. Sequence comparisons with other Asian strains revealed that the Korean strains are closely related to those from China, Japan, and Vietnam. Genotype 3 strains were predominant in Korea before 1993, when genotype 1 strain K93A07 was first isolated. The two genotypes were detected simultaneously in 1994 but since then, only genotype 1 has been isolated in South Korea. Thus, the genotype change occurred according to the year of isolation rather than the geographical origin.