Biodegradable Core-Shell Carriers for Simultaneous Encapsulation of Synergistic Actives
Biodegradable Core-Shell Carriers for Simultaneous Encapsulation of Synergistic Actives
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DOI：
10.1021/ja401422r
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发表时间：
2013-05-29
影响因子：
15
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
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作者：
Windbergs, Maike;Zhao, Yuanjin;Weitz, David A.
在单一载体中同时包封多种活性物质对于药物的协同组合的治疗应用是必不可少的。然而，传统的载体系统通常缺乏对掺入的物质的有效包封和释放，特别是当药物的组合必须以规定比例的浓度释放时。我们提出了一种新的可生物降解的核壳载体系统，在一个一步，无溶剂的过程中制造的微流控芯片;亲水性活性（盐酸阿霉素）被封装在水性核心，而疏水性活性（紫杉醇）被封装在固体壳。可以精确控制颗粒大小和组成，并且可以非常高效地单独装载核和壳。载药颗粒可以干燥并作为粉末储存。我们证明了该系统的有效性，通过同时封装和控制释放的两种协同抗癌药物使用两个癌症衍生值封装其他活性细胞系。这种无溶剂平台技术也是高潜力的成分和化学试剂。
Simultaneous encapsulation of multiple active substances in a single carrier is essential for therapeutic applications of synergistic combinations of drugs. However, traditional carrier systems often lack efficient encapsulation and release of incorporated substances, particularly when combinations of drugs must be released in concentrations of a prescribed ratio. We present a novel biodegradable core shell carrier system fabricated in a one-step, solvent-free process on a microfluidic chip; a hydrophilic active (doxorubicin hydrochloride) is encapsulated in the aqueous core, while a hydrophobic active (paclitaxel) is encapsulated in the solid shell. Particle size and composition can be precisely controlled, and core and shell can be individually loaded with very high efficiency. Drug-loaded particles can be dried and stored as a powder. We demonstrate the efficacy of this system through the simultaneous encapsulation and controlled release of two synergistic anticancer drugs using two cancer-derived value for encapsulation of other active cell lines. This solvent-free platform technology is also of high potential ingredients and chemical reagents.