Rodent models of genetic disease
Rodent models of genetic disease
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DOI：
10.1016/s0959-437x(03)00051-0
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发表时间：
2003-06-01
影响因子：
4
通讯作者：
Brown, SDM
中科院分区：
文献类型：
--
作者：
Cox, RD;Brown, SDM
使用自然变异、自然突变、化学或辐射诱导突变、工程突变和条件工程突变对大鼠和小鼠进行遗传研究，为研究疾病遗传学提供了工具。去年小鼠基因组测序的完成和大鼠基因组测序的进展将使数量性状基因座和诱导突变的分子鉴定成为可能。基于序列的单核苷酸多态性的发现和对近交系单倍型结构的更深入的了解正在重振数量性状基因座作图，目前正在计划进行雄心勃勃的八路重组近交杂交，并重新燃起了对异质种群等现有资源的兴趣。去年，ENU 诱变方法得到了改进，包括平衡染色体和新的基因驱动方法。
The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing the rat genome in the past year will enable the molecular identification of quantitative trait loci and induced mutations. Sequence-based single nucleotide polymorphism discovery and a greater understanding of the haplotype structure of inbred strains is revitalising quantitative trait locus mapping and there are now-plans for an ambitious eight-way recombinant inbred cross and renewed interest in existing resources such as heterogeneous stocks. In the past year there have been refinements to ENU mutagenesis approaches including balancer chromosomes and a new gene-driven approach.