Evaluation of combinations of drugs that inhibit Ehrlich tumor cell ribonucleotide reductase.
Evaluation of combinations of drugs that inhibit Ehrlich tumor cell ribonucleotide reductase.
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发表时间：
1981-05
期刊：
影响因子：
11.2
通讯作者：
A. Sato;J. G. Cory
中科院分区：
文献类型：
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作者：
A. Sato;J. G. Cory
使用等效线图研究了针对非血红素含铁组分和效应物结合组分的试剂组合对艾氏肿瘤细胞核糖核苷酸还原酶的抑制性质。从这些研究中确定，吡唑咪唑(IMPY)与肌苷二醛、IMPY与脱氧鸟苷三磷酸(dGTP)、IMPY与脱氧腺苷三磷酸(dATP)、以及IMPY与脱氧胸苷三磷酸(dTTP)的组合对胞苷二磷酸还原酶具有协同抑制作用。 dATP 和 dGTP 的组合也产生协同抑制作用。羟基脲与IMPY、4-甲基-5-氨基异喹啉缩氨基硫脲(MAIQ)与IMPY、肌苷二醛和5'-脱氧肌苷二醛衍生物的组合产生拮抗抑制作用。利用MAIQ和dATP、MAIQ和dGTP、MAIQ和dTTP、羟基脲和dGTP、以及羟基脲和dTTP的其他组合产生相加的抑制。
The nature of the inhibition of Ehrlich tumor cell ribonucleotide reductase by combinations of agents directed at the non-heme iron-containing component and the effector-binding component was studied with the use of isobolograms. From these studies, it was determined that the combinations of pyrazoloimidazole (IMPY) and dialdehyde of inosine, IMPY and deoxyguanosine triphosphate (dGTP), IMPY and deoxyadenosine triphosphate (dATP), and IMPY and deoxythymidine triphosphate (dTTP) gave synergistic inhibition of cytidine diphosphate reductase. The combination of dATP and dGTP also gave synergistic inhibition. The combinations of hydroxyurea and IMPY, 4-methyl-5-aminoisoquinoline thiosemicarbazone (MAIQ) and IMPY, and dialdehyde of inosine and dialdehyde derivative of 5'-deoxyinosine gave antagonistic inhibition. Other combinations utilizing MAIQ and dATP, MAIQ and dGTP, MAIQ and dTTP, hydroxyurea and dGTP, and hydroxyurea and dTTP gave inhibition which was additive.