Idiopathic chronic eosinophilic pneumonia and asthma: how do they influence each other?
Idiopathic chronic eosinophilic pneumonia and asthma: how do they influence each other?
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DOI：
10.1183/09031936.03.00085603
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发表时间：
2003-07-01
影响因子：
24.3
通讯作者：
Cordier, JF
中科院分区：
文献类型：
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作者：
Marchand, E;Etienne-Mastroianni, B;Cordier, JF
由于特发性慢性嗜酸性粒细胞性肺炎（ICEP）常与哮喘相关，本文对53例ICEP（其中41例（77%）合并哮喘）的临床和随访资料进行了回顾性分析。26例患者在ICEP诊断之前发生哮喘，8例患者同时发生哮喘，7例患者在ICEP诊断后17 ± 12个月发生哮喘，哮喘患者和非哮喘患者ICEP的表现相似，但前者总免疫球蛋白E水平较高。在ICEP诊断时患有哮喘的患者更有可能保持ICEP无复发（56 vs 23%），并且每年随访的复发次数较低（中位数0 vs 0.24）。此外，在最后一次随访时，他们更频繁地接受长期吸入性皮质类固醇治疗（88%对31%）。哮喘在ICEP诊断后恶化，经常需要长期口服皮质类固醇。结论：在特发性慢性嗜酸性粒细胞性肺炎患者中，哮喘患者的复发率低于非哮喘患者，这可能是因为吸入性皮质类固醇的使用率较高。哮喘患者发生特发性慢性嗜酸性粒细胞性肺炎往往与严重哮喘的发展有关。
Since idiopathic chronic eosinophilic pneumonia (ICEP) and asthma are frequently associated, their possible reciprocal influence on clinical presentation and evolution were investigated.The clinical and follow-up features of 53 cases of ICEP, of which 41 (77%) had asthma, were reviewed retrospectively. Asthma preceded the diagnosis of ICEP in 26 patients, was contemporaneous in eight patients, and developed 17+/-12 months after ICEP in seven patients.Presentation of ICEP was similar in asthmatics and nonasthmatics with the exception of a higher level of total immunoglobulin E in the former group. Patients with asthma at the time of diagnosis of ICEP were more likely to remain free of relapse of ICEP (56 versus 23%) and had a lower number of relapses per year of follow-up (median 0 versus 0.24). Moreover, they were treated more frequently with long-term inhaled corticosteroids (88 versus 31%) at last follow-up. Asthma got worse after the diagnosis of ICEP and frequently required long-term oral corticosteroids.To conclude, among patients with idiopathic chronic eosinophilic pneumonia asthmatics have a lower frequency of relapse than nonasthmatics, possibly because of a higher use of inhaled corticosteroids. The occurrence of idiopathic chronic eosinophilic pneumonia in asthmatics is often associated with the development of severe asthma.