Stochastic Bistability and Bifurcation in a Mesoscopic Signaling System with Autocatalytic Kinase
Stochastic Bistability and Bifurcation in a Mesoscopic Signaling System with Autocatalytic Kinase
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DOI：
10.1016/j.bpj.2009.09.055
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发表时间：
2010-01-06
影响因子：
3.4
通讯作者：
Qian, Hong
中科院分区：
文献类型：
--
作者：
Bishop, Lisa M.;Qian, Hong
双稳态是一种广泛存在于自然界中的非线性现象，包括在生物化学反应网络中。过去的确定性化学动力学研究表明，双稳态发生在具有强（立方）非线性的系统中。然而，对于某些介观的，弱非线性（二次）的生化反应系统在一个小的体积，随机性可以诱导双稳态和分岔，没有宏观对应。我们报告了最简单的已知反应，涉及驱动磷酸化-去磷酸化循环动力学与自催化激酶。我们表明，噪声引起的现象与自由能耗散，从而符合开放化学系统理论。先前报道的噪声诱导的无效循环中的双稳态被发现起源于具有慢跃迁的双稳态系统中的激酶同步，如这里所报道的。
Bistability is a nonlinear phenomenon widely observed in nature including in biochemical reaction networks. Deterministic chemical kinetics studied in the past has shown that bistability occurs in systems with strong (cubic) nonlinearity. For certain mesoscopic, weakly nonlinear (quadratic) biochemical reaction systems in a small volume, however, stochasticity can induce bistability and bifurcation that have no macroscopic counterpart. We report the simplest yet known reactions involving driven phosphorylation-dephosphorylation cycle kinetics with autocatalytic kinase. We show that the noise-induced phenomenon is correlated with free energy dissipation and thus conforms with the open-chemical system theory. A previous reported noise-induced bistability in futile cycles is found to have originated from the kinase synchronization in a bistable system with slow transitions, as reported here.