Methods for the synthesis of annulated pyrroles via cyclisation strategies.
Methods for the synthesis of annulated pyrroles via cyclisation strategies.
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DOI：
10.1039/c7ob03144k
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发表时间：
2018-02
影响因子：
3.2
通讯作者：
Wesley J Olivier;Jason A. Smith;Alex C. Bissember
中科院分区：
文献类型：
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作者：
Wesley J Olivier;Jason A. Smith;Alex C. Bissember
吡咯、吡咯烷和吲哚里西啶生物碱是一类重要的天然产物。从历史上看，这些杂环及其衍生物一直是有机合成中重要关注的焦点。在本报告中，我们回顾了通过转化合成环状吡咯的方法，包括：Friedel-Crafts酰化和烷基化、Michael加成、Heck偶联、氢芳化、卡宾插入和自由基环化。
Pyrrole, pyrrolidine, and indolizidine alkaloids represent important classes of natural products. Historically, these heterocycles and their derivatives have been the focus of significant interest in organic synthesis. In this report, we review the methods that have been employed to synthesise annulated pyrroles via transformations that include: Friedel-Crafts acylations and alkylations, Michael additions, Heck couplings, hydroarylations, carbenoid insertions, and radical cyclisations.