Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema
Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema
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DOI：
10.1016/j.ophtha.2007.12.004
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发表时间：
2008-08-01
期刊：
影响因子：
13.7
通讯作者：
Qin, Haijing
中科院分区：
文献类型：
--
作者：
Browning, David J.;Glassman, Adam R.;Qin, Haijing
目的：探讨光学相干断层扫描（OCT）在糖尿病性黄斑水肿（DME）研究中的测量方法和OCT数据分析方法。设计：利用2项DME研究的数据，对OCT变量对和3种分析方法的结果进行关联分析。参与者：来自改良的糖尿病视网膜病变早期治疗研究（mETDRS）的263名受试者与改良的黄斑网格（MMG）光凝治疗DME的研究，以及来自DME日变化研究的96名受试者。方法：计算基线时OCT变量对和变量随时间变化的相关性。分析黄斑厚度变化的3个指标：视网膜厚度的绝对变化、视网膜厚度的相对变化、视网膜增厚的相对变化，比较OCT测量变化的分布、OCT测量变化的预测因素及治疗组结果。主要结果测量：不同OCT变量和分析方法结果的一致性。结果：中心点厚度与基线时中心子场平均厚度（CSMT）高度相关（0.98 ~ 0.99）。视网膜厚度的绝对变化和相对变化的CSMT变化的分布近似正态分布，但视网膜增厚的相对变化不符合正态分布。当使用视网膜厚度的绝对变化时，mETDRS组的黄斑变薄明显大于MMG组，但当使用相对厚度变化和相对增厚变化时，则没有。与视网膜厚度的绝对或相对变化不同，黄斑增厚的相对变化在基线增厚程度较轻的眼睛中提供了不稳定的数据。结论：中央子野平均厚度是中央黄斑的首选OCT测量方法，因为它具有较高的重复性和与其他中央黄斑测量方法的相关性。当中央黄斑不太重要时，可选择黄斑总体积。视网膜厚度的绝对变化是研究轻度黄斑增厚的首选分析方法。当视网膜增厚较严重时，增厚的相对改变可能更可取。
Objective: To evaluate optical coherence tomography (OCT) measurements and methods of analysis of OCT data in studies of diabetic macular edema (DME).Design: Associations of pairs of OCT variables and results of 3 analysis methods using data from 2 studies of DME.Participants: Two hundred sixty-three subjects from a study of modified Early Treatment of Diabetic Retinopathy Study (mETDRS) versus modified macular grid (MMG) photocoagulation for DME and 96 subjects from a study of diurnal variation of DME.Methods: Correlations were calculated for pairs of OCT variables at baseline and for changes in the variables over time. Distribution of OCT measurement changes, predictive factors for OCT measurement changes, and treatment group outcomes were compared when 3 measures of change in macular thickness were analyzed: absolute change in retinal thickness, relative change in retinal thickness, and relative change in retinal thickening.Main Outcome Measures: Concordance of results using different OCT variables and analysis methods.Results: Center point thickness correlated highly with central subfield mean thickness (CSMT) at baseline (0.98-0.99). The distributions of changes in CSMT were approximately normally distributed for absolute change in retinal thickness and relative change in retinal thickness, but not for relative change in retinal thickening. Macular thinning in the mETDRS group was significantly greater than in the MMG group when absolute change in retinal thickness was used, but not when relative change in thickness and relative change in thickening were used. Relative change in macular thickening provides unstable data in eyes with mild degrees of baseline thickening, unlike the situation with absolute or relative change in retinal thickness.Conclusions: Central subfield mean thickness is the preferred OCT measurement for the central macula because of its higher reproducibility and correlation with other measurements of the central macula. Total macular volume may be preferred when the central macula is less important. Absolute change in retinal thickness is the preferred analysis method in studies involving eyes with mild macular thickening. Relative change in thickening may be preferable when retinal thickening is more severe.